{"id":"W4308685395","doi":"10.1039/d2sc04496j","title":"Iminologous epoxide ring-closure","year":2022,"lang":"en","type":"article","venue":"Chemical Science","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Connaught Fund","keywords":"Epoxide; Chemistry; Ring (chemistry); Nitrile; Nucleophile; Nucleophilic addition; Stereochemistry; Combinatorial chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552773,0.0004322533,0.0001141731,0.0002347434,0.0002258318,0.0001482878,0.0003301285,0.0003534919,0.003674862],"category_scores_gemma":[0.0002057416,0.0001000543,0.0001867245,0.0001810134,0.0002213233,0.0003438047,0.0003176048,0.0006110764,0.0007556861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998106,"about_ca_system_score_gemma":0.0003064534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005670284,"about_ca_topic_score_gemma":0.001010491,"domain_scores_codex":[0.9998413,0.0000168438,0.000007231519,0.00003034953,0.00002074144,0.00008345098],"domain_scores_gemma":[0.9999357,0.000009771592,0.00001880612,0.0000131108,0.000008897347,0.00001357588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008639076,0.0002427504,0.0007854401,0.00030492,0.00003997045,0.0007918277,0.0003120706,0.001028031,0.9661509,0.007650221,0.001829088,0.02000091],"study_design_scores_gemma":[0.00004330911,0.0003125637,0.001085852,0.00001294933,0.000009715473,0.000277027,0.00004827275,0.0006417269,0.9900782,0.0004477962,0.00703039,0.00001221371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436141,0.0017238,0.01897001,0.0004389018,0.0001874674,0.0002452176,0.001107498,0.0002668963,0.03344615],"genre_scores_gemma":[0.9941077,0.0004599633,0.002001206,0.00006132005,0.000005544485,0.00003157356,0.0002735299,0.00001314619,0.003046024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003674862,"threshold_uncertainty_score":0.01229364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879328887955043,"score_gpt":0.2711386659578632,"score_spread":0.2523453770783127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}