{"id":"W4308695772","doi":"10.1101/2022.11.09.515839","title":"TREM1 <sup>+</sup> regulatory myeloid cells expand in steatohepatitis-HCC and associate with poor prognosis and therapeutic resistance to immune checkpoint blockade","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fondation ARC pour la Recherche sur le Cancer; Achievement Rewards for College Scientists Foundation","keywords":"Myeloid; Immune checkpoint; Cancer research; Immunotherapy; Population; Immunology; CD33; Biology; Medicine; Immune system; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747412,0.0001117873,0.0001499256,0.0005066296,0.000124228,0.0002166607,0.00008911407,0.0001371294,0.001776544],"category_scores_gemma":[0.0001433142,0.0001069066,0.0001098234,0.0002229731,0.0001227564,0.00009639787,0.0001952198,0.0002153032,0.0003458633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007137081,"about_ca_system_score_gemma":0.0000554947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001653717,"about_ca_topic_score_gemma":0.0001605207,"domain_scores_codex":[0.9999506,0.000009910032,0.000005220596,0.00001213316,0.000009162852,0.00001285986],"domain_scores_gemma":[0.9998702,0.0000167454,0.00005125601,0.00001402518,0.0000130227,0.00003477674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002796534,0.00009242808,0.4870173,0.00008711737,0.00005899611,0.001189082,0.0001863897,0.0003863435,0.4902289,0.0003656913,0.0005397288,0.01705156],"study_design_scores_gemma":[0.00002429217,0.0003741671,0.9618458,0.000008087908,0.00003049371,0.0046875,0.0001664564,0.002714343,0.02824824,0.0002791968,0.001613739,0.000007714635],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989069,0.0001728226,0.0004460839,0.00001453633,0.000001561366,0.000004877197,0.0001302548,0.00002175242,0.00030127],"genre_scores_gemma":[0.9990618,0.00006064864,0.0002917933,0.00001245466,0.000005798157,0.000006173266,0.0002531183,0.000004300897,0.0003038824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001776544,"threshold_uncertainty_score":0.00594312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008511055081767643,"score_gpt":0.1898192869622186,"score_spread":0.1813082318804509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}