{"id":"W4308721880","doi":"10.3389/fphar.2022.1023522","title":"Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Hemophagocytosis; Hemophagocytic lymphohistiocytosis; Macrophage activation syndrome; Medicine; Eosinophilia; Adverse drug reaction; Dermatology; Drug eruption; Maculopapular rash; Immunology; Rash; Disease; Drug; Pathology; Pharmacology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003575039,0.0002473169,0.0005055742,0.0005275296,0.000298621,0.00001022167,0.00008501365,0.00008791826,0.00003456599],"category_scores_gemma":[0.00003044041,0.0002431178,0.00005812587,0.0005492728,0.0001166247,0.0001616797,0.0001092469,0.0008582992,0.00000531971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001025505,"about_ca_system_score_gemma":0.0002921516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000309455,"about_ca_topic_score_gemma":0.00002585886,"domain_scores_codex":[0.9980431,0.0002302018,0.0004307038,0.0005930385,0.0002777353,0.000425253],"domain_scores_gemma":[0.9991138,0.00006705891,0.0002447761,0.0003117481,0.00006197179,0.0002006487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001181457,0.001857866,0.06559065,0.000625953,0.001509328,0.6773894,0.004949715,0.0008390389,0.1785654,0.00006350451,0.01499188,0.0524358],"study_design_scores_gemma":[0.0123564,0.0003361121,0.007148617,0.00008215081,0.001314937,0.9410481,0.0132095,0.004433962,0.003387725,0.00006906123,0.01598822,0.0006252067],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915473,0.0006102366,0.0001056004,0.0007915793,0.004106519,0.001103118,0.00001447722,0.0001295589,0.00159157],"genre_scores_gemma":[0.997001,0.00005638611,0.0003839464,0.0003556913,0.0001811474,0.0004203962,0.00004367467,0.00005668853,0.001501096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2636587,"threshold_uncertainty_score":0.9914054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021231365528459,"score_gpt":0.2702935192619139,"score_spread":0.2600812056066293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}