{"id":"W4308722894","doi":"10.3390/cancers14225485","title":"T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"China Scholarship Council; Deutsche Forschungsgemeinschaft; St. Baldrick's Foundation","keywords":"CRISPR; Genome editing; Chimeric antigen receptor; Adoptive cell transfer; Cancer research; Cytotoxic T cell; Viral vector; Genetic enhancement; T-cell receptor; Cas9; Immunotherapy; T cell; Transduction (biophysics); Biology; Immunology; Gene; Immune system; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002815183,0.0003941065,0.0003335906,0.000332615,0.0001582864,0.0004284155,0.0002934923,0.0004611122,0.001089861],"category_scores_gemma":[0.0001479064,0.0001447588,0.0002955271,0.0001713664,0.000292042,0.0003032387,0.0002064181,0.0006992032,0.000337785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260304,"about_ca_system_score_gemma":0.0002109818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006117573,"about_ca_topic_score_gemma":0.0005906927,"domain_scores_codex":[0.999629,0.00006686517,0.00004413104,0.00009085888,0.00009698349,0.00007214669],"domain_scores_gemma":[0.9999089,0.0000183109,0.000026543,0.00000970365,0.00001333639,0.00002306383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001425163,0.00007826185,0.00007341512,0.00004156611,0.000006095234,0.00002801092,0.00001521223,0.000122718,0.9980164,0.0001118106,0.00002354026,0.001340447],"study_design_scores_gemma":[0.00004110935,0.001131922,0.0007598673,0.000004757346,0.00005133296,0.0003017714,0.0000186459,0.0008901971,0.9950539,0.00004462459,0.00169576,0.000006035107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869679,0.00158519,0.008882883,0.00007147992,0.00005974416,0.0001129785,0.0002000932,0.0001168395,0.002002843],"genre_scores_gemma":[0.9922588,0.0009655504,0.004773817,0.00004878512,0.00001423027,0.00008919378,0.000238343,0.00002560135,0.001585645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089861,"threshold_uncertainty_score":0.003645957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03485692058424868,"score_gpt":0.2863379827032491,"score_spread":0.2514810621190005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}