{"id":"W4308735505","doi":"10.1038/s41541-022-00561-2","title":"Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Q & T Research; Manna Research; Université Laval; McGill University Health Centre; Medicago (Canada)","funders":"","keywords":"Medicine; Immunogenicity; Vaccination; Adverse effect; ELISPOT; Placebo; Tolerability; Interim analysis; Randomized controlled trial; Reactogenicity; Immunology; Neutralizing antibody; Internal medicine; Antibody; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001175085,0.0003462295,0.0006618359,0.0001195994,0.0002233471,0.0003397827,0.0002122621,0.0006782564,0.001283854],"category_scores_gemma":[0.001100883,0.0001855319,0.0006210882,0.0001725212,0.0002953387,0.0003966113,0.0001742701,0.0008166968,0.0002747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002477546,"about_ca_system_score_gemma":0.0004935652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004434936,"about_ca_topic_score_gemma":0.0005013461,"domain_scores_codex":[0.999675,0.000127896,0.00003201772,0.00005216444,0.00005800027,0.00005483861],"domain_scores_gemma":[0.9996313,0.00006695429,0.0001246742,0.00003284578,0.00005058714,0.0000936506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7422863,0.02654778,0.04601483,0.0006105609,0.0007198502,0.0003330651,0.0006349849,0.001149474,0.0776824,0.0001843241,0.00120602,0.1026304],"study_design_scores_gemma":[0.04048437,0.8668817,0.08233234,0.00004489206,0.0004436891,0.0002842352,0.0001687089,0.0006322027,0.006684795,0.0001387597,0.001882487,0.0000219402],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989542,0.0003159422,0.000103731,0.0000405716,0.00001634165,0.0001380536,0.0001758738,0.000005423152,0.0002498334],"genre_scores_gemma":[0.9981342,0.0002929653,0.0002393518,0.0001358312,0.00003499412,0.0003316732,0.0003349887,0.000002078458,0.00049394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001283854,"threshold_uncertainty_score":0.006214559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458394576189302,"score_gpt":0.3074810537787257,"score_spread":0.2828971080168327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}