{"id":"W4308739329","doi":"10.1016/j.jpha.2022.10.004","title":"Comparison of different approaches for direct coupling of solid-phase microextraction to mass spectrometry for drugs of abuse analysis in plasma","year":2022,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Analysis","topic":"Analytical chemistry methods development","field":"Chemistry","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Narodowym Centrum Nauki; Shimadzu","keywords":"Solid-phase microextraction; Chemistry; Chromatography; Mass spectrometry; Analytical Chemistry (journal); Gas chromatography–mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002664128,0.001399029,0.0008265675,0.001687966,0.000482662,0.0008117809,0.001068983,0.001111407,0.0007973482],"category_scores_gemma":[0.003543086,0.0006574155,0.001110458,0.0009869011,0.0006156153,0.001027389,0.0009323513,0.001023368,0.0007235673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004922075,"about_ca_system_score_gemma":0.0007773001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00107069,"about_ca_topic_score_gemma":0.00286377,"domain_scores_codex":[0.9960023,0.0007776029,0.0002915744,0.0006993826,0.002031657,0.0001974442],"domain_scores_gemma":[0.9987703,0.0005146038,0.0001449271,0.0001049211,0.0004154464,0.00004983059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000617437,0.0001312596,0.001441395,0.001893681,0.0004716785,0.0002005523,0.0002252875,0.0007233411,0.9481591,0.0004563057,0.0005983695,0.04508158],"study_design_scores_gemma":[0.00004894942,0.001275198,0.007186113,0.000104049,0.0004652131,0.001192998,0.0001435031,0.004021389,0.9727166,0.0002665755,0.01245031,0.0001290577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6370857,0.1011681,0.2408596,0.001012431,0.001340931,0.002033623,0.002476664,0.001659235,0.01236373],"genre_scores_gemma":[0.5330111,0.07246584,0.3835917,0.001034367,0.0003022554,0.001584293,0.002531579,0.0004153829,0.005063513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002664128,"threshold_uncertainty_score":0.01408947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1084848775102187,"score_gpt":0.4462887125640216,"score_spread":0.3378038350538028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}