{"id":"W4308741991","doi":"10.1016/j.jchf.2022.09.012","title":"Functional and Symptomatic Clinical Trial Endpoints","year":2022,"lang":"en","type":"review","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Janssen Pharmaceuticals; National Heart, Lung, and Blood Institute; Sanofi Pasteur; U.S. Food and Drug Administration; Medtronic; ResMed; Bayer Fund; Boston Scientific Corporation; Cytokinetics; AbbVie; Gilead Sciences; National Institutes of Health; Roche; Vifor Pharma; Sphingotec GmbH; Respicardia; Novartis; Merck; GlaxoSmithKline; Bristol-Myers Squibb; AstraZeneca; Pfizer; Edwards Lifesciences; Boehringer Ingelheim; Amgen; American Heart Association; Abbott Laboratories","keywords":"Medicine; Heart failure; Clinical trial; Quality of life (healthcare); Intensive care medicine; Clinical endpoint; Clinical research; Food and drug administration; Physical therapy; Collaboratory; Internal medicine; Medical emergency; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001116435,0.0005320096,0.002669349,0.0003018393,0.0002012414,0.00005909295,0.00009942261,0.0004140012,0.00795217],"category_scores_gemma":[0.0002877371,0.0003987189,0.001082643,0.000315812,0.00008870666,0.00007718701,0.0002691166,0.0009757265,0.0009162085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815995,"about_ca_system_score_gemma":0.0005604624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000777088,"about_ca_topic_score_gemma":0.000006506316,"domain_scores_codex":[0.9964594,0.0005139288,0.001209347,0.0007869271,0.0006094939,0.0004209652],"domain_scores_gemma":[0.9979845,0.000707294,0.000229608,0.0006659161,0.00002792708,0.0003847204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005646928,0.0004152351,0.00004322241,0.005856828,0.0007002149,0.00009735738,0.00001279426,1.694214e-8,2.871399e-8,0.0001287449,0.4637458,0.5284351],"study_design_scores_gemma":[0.0153381,0.001069778,0.00004397813,0.001965915,0.002795153,0.0003508011,0.00002787618,0.000002100524,3.326415e-8,0.00001715708,0.9780921,0.0002970088],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005709031,0.9865381,0.000009375015,0.005972015,0.001381648,0.004910617,0.00002798782,0.0002142252,0.0008889568],"genre_scores_gemma":[0.000004141715,0.9863648,0.003048018,0.0006339788,0.001680759,0.00086709,0.0005869995,0.00008938296,0.006724804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.528138,"threshold_uncertainty_score":0.9998617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1463779841573124,"score_gpt":0.4045722291925405,"score_spread":0.2581942450352281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}