{"id":"W4308741991","doi":"10.1016/j.jchf.2022.09.012","title":"Functional and Symptomatic Clinical Trial Endpoints","year":2022,"lang":"en","type":"review","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Janssen Pharmaceuticals; National Heart, Lung, and Blood Institute; Sanofi Pasteur; U.S. Food and Drug Administration; Medtronic; ResMed; Bayer Fund; Boston Scientific Corporation; Cytokinetics; AbbVie; Gilead Sciences; National Institutes of Health; Roche; Vifor Pharma; Sphingotec GmbH; Respicardia; Novartis; Merck; GlaxoSmithKline; Bristol-Myers Squibb; AstraZeneca; Pfizer; Edwards Lifesciences; Boehringer Ingelheim; Amgen; American Heart Association; Abbott Laboratories","keywords":"Medicine; Heart failure; Clinical trial; Quality of life (healthcare); Intensive care medicine; Clinical endpoint; Clinical research; Food and drug administration; Physical therapy; Collaboratory; Internal medicine; Medical emergency; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01823788,0.001125915,0.004135945,0.002768942,0.0003191479,0.001634728,0.001247418,0.001528953,0.01249697],"category_scores_gemma":[0.01990275,0.000187553,0.005040918,0.002766944,0.0004968253,0.0008994298,0.0008112669,0.002313452,0.001265725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001233752,"about_ca_system_score_gemma":0.002066149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008079254,"about_ca_topic_score_gemma":0.002144515,"domain_scores_codex":[0.9885753,0.005916285,0.002729806,0.0005689947,0.001973092,0.0002364454],"domain_scores_gemma":[0.9901305,0.006231827,0.001920917,0.0002534303,0.001235391,0.0002278235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00419158,0.0002452261,0.001636243,0.3106186,0.01605637,0.0001156159,0.0001695489,0.0008479572,0.0007050955,0.007596817,0.0681414,0.5896755],"study_design_scores_gemma":[0.009376467,0.002763117,0.01776361,0.3095761,0.04279795,0.0009218259,0.0002425799,0.001131598,0.001227477,0.01316826,0.6008619,0.0001691077],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001441467,0.976083,0.00187948,0.00201926,0.001117192,0.003293535,0.004342534,0.00006374814,0.009759782],"genre_scores_gemma":[0.05076536,0.904764,0.008572936,0.006453775,0.002474294,0.01211623,0.008258932,0.00004905169,0.00654538],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01823788,"threshold_uncertainty_score":0.09645224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1463779841573124,"score_gpt":0.4045722291925405,"score_spread":0.2581942450352281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}