{"id":"W4308767606","doi":"10.1021/acs.analchem.2c03067","title":"How Choice of Model Membrane Affects Protein–Glycosphingolipid Interactions: Insights from Native Mass Spectrometry","year":2022,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Chemistry; Electrospray ionization; Ganglioside; Membrane; Glycosphingolipid; Liposome; Cooperativity; Lipid bilayer; Mass spectrometry; Biophysics; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004791698,0.0004712126,0.0003437197,0.000162314,0.0002734319,0.0005622105,0.000342039,0.0005574009,0.0007314859],"category_scores_gemma":[0.0005197109,0.0001797361,0.0002357918,0.0001493852,0.0003374924,0.0006930233,0.0003744287,0.0006793882,0.0002418149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000415357,"about_ca_system_score_gemma":0.0002114174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007281164,"about_ca_topic_score_gemma":0.0006308992,"domain_scores_codex":[0.9997905,0.00003244036,0.00001292302,0.00005838336,0.00006514619,0.00004058802],"domain_scores_gemma":[0.9998316,0.00005874634,0.00003913432,0.00001486012,0.00003408334,0.00002163545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004245849,0.00001401488,0.0003471042,0.00005539448,0.000007127673,0.00004668707,0.00002266983,0.000148104,0.9983407,0.0001424448,0.00003021885,0.0008030178],"study_design_scores_gemma":[0.000008388228,0.00007869462,0.003795218,0.00001445141,0.00001847899,0.0001888578,0.0001281168,0.009887538,0.9843052,0.0003108603,0.001246801,0.00001755945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848366,0.001391314,0.01205796,0.0002412763,0.00003014474,0.00002862492,0.0002966185,0.0001096401,0.001007744],"genre_scores_gemma":[0.9846186,0.002431759,0.01156839,0.0001728397,0.00001014175,0.00005312357,0.0003947884,0.00005154092,0.0006988795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007314859,"threshold_uncertainty_score":0.003013611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350473860221742,"score_gpt":0.2617791504570144,"score_spread":0.248274411854797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}