{"id":"W4308769716","doi":"10.1021/acschembio.2c00707","title":"Discovery of 3′-<i>O</i>-β-Glucosyltubercidin and the Nucleoside Specific Glycosyltransferase AvpGT through Genome Mining","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glycosyl; Glycosyltransferase; Biochemistry; Escherichia coli; Chemistry; Nucleoside; Enzyme kinetics; Gene; Gene cluster; Biology; Stereochemistry; Enzyme; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710165,0.000353218,0.0005508161,0.0006492559,0.0001282725,0.0005825354,0.0002930388,0.0003951933,0.00032999],"category_scores_gemma":[0.0004216575,0.0001970833,0.0005626093,0.001333068,0.0001170304,0.0002233552,0.0002105879,0.0004125318,0.0002981176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615432,"about_ca_system_score_gemma":0.0002806449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007415045,"about_ca_topic_score_gemma":0.0009709672,"domain_scores_codex":[0.9998827,0.00001428053,0.00000915532,0.00004263119,0.00003703477,0.00001418684],"domain_scores_gemma":[0.9997671,0.00004653012,0.00009131579,0.00001772222,0.00004138182,0.00003595957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001745584,0.00003783755,0.005619678,0.0001865439,0.00003522652,0.000463291,0.00006090568,0.0006682595,0.9754131,0.0001596529,0.0001276244,0.0170534],"study_design_scores_gemma":[0.00005577653,0.0005642709,0.09981821,0.00007568179,0.0003532803,0.004080662,0.0003212223,0.02228235,0.8479566,0.0008576356,0.02358483,0.00004949988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555396,0.00259505,0.03458008,0.0002157691,0.00001822656,0.0001235794,0.004629875,0.000435866,0.00186191],"genre_scores_gemma":[0.9116083,0.002018817,0.06983437,0.0001020117,0.00001768993,0.00006902013,0.01494309,0.0001279146,0.00127878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007415045,"threshold_uncertainty_score":0.001897633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358293823509787,"score_gpt":0.2138024166584492,"score_spread":0.2002194784233514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}