{"id":"W4308770081","doi":"10.1038/s41598-022-21132-4","title":"Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neurological Complications and Syndromes","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Universidade de São Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Swedish Foundation for International Cooperation in Research and Higher Education","keywords":"Neuroprotection; Proinflammatory cytokine; Neuroinflammation; Klotho; Astrocyte; Neurodegeneration; Tumor necrosis factor alpha; Microglia; Chemistry; Cell biology; Biology; Pharmacology; Inflammation; Endocrinology; Internal medicine; Immunology; Medicine; Central nervous system; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152311,0.0005252751,0.0004822116,0.0002322123,0.000198305,0.0002580527,0.0001873942,0.000219039,0.0009982422],"category_scores_gemma":[0.00006878458,0.00009416062,0.0003828285,0.0002089963,0.0001817724,0.0001849088,0.0001756881,0.0007696915,0.0003162381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002332306,"about_ca_system_score_gemma":0.0004844541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00212728,"about_ca_topic_score_gemma":0.004475966,"domain_scores_codex":[0.9998829,0.00001007692,0.00001665251,0.00002142041,0.00003513696,0.00003370537],"domain_scores_gemma":[0.9999398,0.000005517693,0.00001217475,0.000007275357,0.00001755989,0.00001767505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002782557,0.00008245116,0.0001096762,0.00011421,0.00001228059,0.0001191381,0.00004061321,0.00006691696,0.9977012,0.00004487326,0.00009680411,0.00133353],"study_design_scores_gemma":[0.00003800047,0.0006772373,0.003049728,0.00002004813,0.00004137204,0.0001703339,0.00005183242,0.0003749396,0.993515,0.00004349626,0.00201208,0.000005991289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871027,0.004746087,0.003568753,0.0001899843,0.0001675324,0.00009322003,0.001140379,0.0001395263,0.002851832],"genre_scores_gemma":[0.9836015,0.004380869,0.005092581,0.0001176541,0.00004825918,0.0001843489,0.002207255,0.00002284063,0.004344735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00212728,"threshold_uncertainty_score":0.004229844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03073177842634599,"score_gpt":0.2786088524718577,"score_spread":0.2478770740455117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}