{"id":"W4308770081","doi":"10.1038/s41598-022-21132-4","title":"Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neurological Complications and Syndromes","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Universidade de São Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Swedish Foundation for International Cooperation in Research and Higher Education","keywords":"Neuroprotection; Proinflammatory cytokine; Neuroinflammation; Klotho; Astrocyte; Neurodegeneration; Tumor necrosis factor alpha; Microglia; Chemistry; Cell biology; Biology; Pharmacology; Inflammation; Endocrinology; Internal medicine; Immunology; Medicine; Central nervous system; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005092016,0.0001065487,0.0002457813,0.0002336068,0.0002844764,0.00002367338,0.00008303014,0.00003855795,0.0003263721],"category_scores_gemma":[0.0001709958,0.00009104036,0.0000843686,0.0009377745,0.0001854281,0.00009338804,0.0001083882,0.0003783063,0.000003667642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001000918,"about_ca_system_score_gemma":0.0001735166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009679659,"about_ca_topic_score_gemma":0.000001727765,"domain_scores_codex":[0.9980703,0.00014303,0.000444708,0.000575974,0.0005907,0.0001753181],"domain_scores_gemma":[0.9989563,0.00003048788,0.0003078426,0.0004784659,0.0001492112,0.0000776862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009909525,0.0003631454,0.00527534,0.00003170758,0.000009745171,0.000644998,0.0001365431,0.0001662264,0.989807,0.00002301258,0.002904934,0.0005382169],"study_design_scores_gemma":[0.0009586614,0.0008339509,0.7580686,0.00003091718,0.00004301596,0.002611545,0.000275486,0.0001898605,0.1811579,0.003686881,0.05188898,0.0002541504],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946018,0.0000257533,0.00002999552,0.0006181787,0.001439963,0.0006186216,0.00001182139,0.00005992617,0.002593951],"genre_scores_gemma":[0.997713,0.000002544735,0.00009347373,0.0002899214,0.0000222231,0.0001210029,0.000243263,0.00001127067,0.001503312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8086491,"threshold_uncertainty_score":0.3712518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03073177842634599,"score_gpt":0.2786088524718577,"score_spread":0.2478770740455117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}