{"id":"W4308770246","doi":"10.1212/wnl.0000000000201572","title":"Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Wolfson Foundation; Brain Research Trust; Canadian Institutes of Health Research; Prothena; National Institute for Health and Care Research; Northern California Institute for Research and Education; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; University College London Hospitals NHS Foundation Trust; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Neurodegeneration; Disease; Medicine; Cognitive decline; Baseline (sea); Cognition; Cognitive impairment; Physical medicine and rehabilitation; Gerontology; Neuroscience; Internal medicine; Psychology; Dementia; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002863166,0.0006726531,0.0003880437,0.000864464,0.0002150599,0.0006717095,0.0003847703,0.0006745028,0.0009757125],"category_scores_gemma":[0.004581408,0.0001652302,0.001152383,0.0005772992,0.0001831597,0.0005039131,0.0005622587,0.0006377809,0.0002552407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338411,"about_ca_system_score_gemma":0.0005096963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007024709,"about_ca_topic_score_gemma":0.01125798,"domain_scores_codex":[0.9996623,0.0001313193,0.00003155684,0.00008382333,0.00005169143,0.00003925118],"domain_scores_gemma":[0.9982861,0.0006411626,0.0004734228,0.0001754795,0.0002209263,0.0002030483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009804339,0.00006251812,0.9908475,0.00002957925,0.0003237577,0.00001462875,0.00003435234,0.0004870112,0.0001214774,0.00001727858,0.0002822462,0.006799154],"study_design_scores_gemma":[0.00006604614,0.0006965603,0.991928,0.00003025541,0.0003042187,0.00008748082,0.00008238614,0.006005277,0.0002460245,0.0001995302,0.0003429634,0.0000112777],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961743,0.0009837992,0.0009079057,0.0001790106,0.00003123417,0.00002771012,0.0009974823,0.00003450518,0.0006639843],"genre_scores_gemma":[0.998398,0.0001867766,0.000503864,0.00004210952,0.00002726497,0.00001715007,0.0006402665,0.000002708065,0.000181843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007024709,"threshold_uncertainty_score":0.01514208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028357685359645,"score_gpt":0.2945757283248268,"score_spread":0.2742921514712303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}