{"id":"W4308771654","doi":"10.1007/s00467-022-05789-7","title":"Shared genetic risk across different presentations of gene test–negative idiopathic nephrotic syndrome","year":2022,"lang":"en","type":"article","venue":"Pediatric Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Women's College Hospital","funders":"Medical Research Council; NIHR BioResource; National Institute for Health and Care Research; Department of Health and Social Care; Kidney Foundation of Canada; Kidney Research UK; Cancer Research UK; Wellcome Trust; NHS Blood and Transplant","keywords":"Focal segmental glomerulosclerosis; Nephrotic syndrome; Medicine; Genome-wide association study; Immunology; Nephropathy; Disease; Minimal change disease; Membranous nephropathy; Glomerulonephritis; Internal medicine; Oncology; Genetics; Gene; Genotype; Endocrinology; Biology; Kidney; Single-nucleotide polymorphism; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006292058,0.0007766348,0.0004810461,0.001606569,0.0004483885,0.0008293074,0.0005140038,0.0006340372,0.002139285],"category_scores_gemma":[0.002165471,0.000212945,0.0007341428,0.001166946,0.0007087307,0.0002859808,0.001106035,0.0004053859,0.0001924492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002817599,"about_ca_system_score_gemma":0.0002505637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002207403,"about_ca_topic_score_gemma":0.002649039,"domain_scores_codex":[0.9988105,0.0002293638,0.000133346,0.0005036068,0.0002000863,0.0001231368],"domain_scores_gemma":[0.9988882,0.0002837056,0.0004655772,0.0001083935,0.00008548432,0.0001686296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000385229,0.00002765521,0.9902911,0.00002010456,0.0004472281,0.0008072377,0.0001290747,0.0002356747,0.004963517,0.0002401248,0.0001121124,0.002341029],"study_design_scores_gemma":[0.00001858698,0.0001052253,0.9943922,0.00001591004,0.0001891825,0.003298045,0.00009899523,0.0006283564,0.0005781061,0.0003705873,0.0002935491,0.00001129996],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988256,0.0001173933,0.0003577919,0.00002619912,0.000005998527,0.000006442394,0.0002287084,0.00001012542,0.0004217148],"genre_scores_gemma":[0.9991736,0.00004142879,0.0003497405,0.00002036743,0.000007141904,0.000005056969,0.0003240652,0.000007095488,0.00007143876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002207403,"threshold_uncertainty_score":0.007156551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155279540349312,"score_gpt":0.2670289595858893,"score_spread":0.2554761641823962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}