{"id":"W4308771654","doi":"10.1007/s00467-022-05789-7","title":"Shared genetic risk across different presentations of gene test–negative idiopathic nephrotic syndrome","year":2022,"lang":"en","type":"article","venue":"Pediatric Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Women's College Hospital","funders":"Medical Research Council; NIHR BioResource; National Institute for Health and Care Research; Department of Health and Social Care; Kidney Foundation of Canada; Kidney Research UK; Cancer Research UK; Wellcome Trust; NHS Blood and Transplant","keywords":"Focal segmental glomerulosclerosis; Nephrotic syndrome; Medicine; Genome-wide association study; Immunology; Nephropathy; Disease; Minimal change disease; Membranous nephropathy; Glomerulonephritis; Internal medicine; Oncology; Genetics; Gene; Genotype; Endocrinology; Biology; Kidney; Single-nucleotide polymorphism; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944003,0.000245961,0.0006236288,0.0002527902,0.0003494616,0.00001315387,0.0002169009,0.0000842284,0.0006928699],"category_scores_gemma":[0.0005664021,0.0002217607,0.0002607918,0.0007235809,0.0001648314,0.00005286736,0.000272797,0.0004477486,0.00003663986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005410697,"about_ca_system_score_gemma":0.0001721709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798419,"about_ca_topic_score_gemma":0.00001205635,"domain_scores_codex":[0.9976469,0.0003098211,0.0006216222,0.000453766,0.0004837704,0.0004841588],"domain_scores_gemma":[0.9982429,0.0005298507,0.000407791,0.0004591729,0.0001328267,0.0002275244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004112208,0.00101388,0.9915475,0.0003204761,0.0001849062,0.0005875131,0.001127534,0.0009214286,0.0020829,0.00003119085,0.001286137,0.0004853444],"study_design_scores_gemma":[0.001890475,0.001569449,0.9923624,0.000004061915,0.0008750062,0.0006589047,0.0003554637,0.0007300689,0.0001070032,0.001139621,0.0001222679,0.0001852718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917942,0.005689787,0.0002901407,0.0003372861,0.000214844,0.0007571694,0.0008016782,0.00006431891,0.00005058599],"genre_scores_gemma":[0.9974147,0.0009922688,0.0003330771,0.0003340324,0.0002965326,0.0003853798,0.00006426819,0.00003758521,0.0001421692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005620497,"threshold_uncertainty_score":0.9043138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155279540349312,"score_gpt":0.2670289595858893,"score_spread":0.2554761641823962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}