{"id":"W4308775132","doi":"10.1007/s00280-022-04491-7","title":"Fluoropyrimidine-associated toxicity and DPYD variants c.85T>C, c.496A>G, and c.1236G>A: impact of haplotype","year":2022,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"DPYD; Dihydropyrimidine dehydrogenase; Capecitabine; Toxicity; Haplotype; Internal medicine; Medicine; Pharmacogenetics; Linkage disequilibrium; Dosing; Fluorouracil; Genotyping; Pharmacology; Genotype; Thymidylate synthase; Oncology; Chemotherapy; Biology; Cancer; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003373224,0.0002453667,0.0002457305,0.0001906699,0.0002498254,0.0004019306,0.0002123694,0.0004794713,0.004691071],"category_scores_gemma":[0.001369234,0.000110397,0.0004905407,0.0004216609,0.0002011683,0.0002797473,0.0002083937,0.0005030574,0.0002067879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224997,"about_ca_system_score_gemma":0.0002092886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004083438,"about_ca_topic_score_gemma":0.004285959,"domain_scores_codex":[0.9996895,0.00008030798,0.00003681413,0.00009357311,0.00004186784,0.00005798512],"domain_scores_gemma":[0.9994061,0.0002026432,0.0001850526,0.00005206294,0.00003973823,0.0001144423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009509576,0.0001902647,0.9607177,0.00007544686,0.001022398,0.001680477,0.000186135,0.0004514178,0.009281862,0.0003924244,0.0009513577,0.01554084],"study_design_scores_gemma":[0.00007277575,0.0007721945,0.9941009,0.00002854898,0.0004648314,0.001889702,0.0001228461,0.0004679636,0.0005781931,0.0002990492,0.001190669,0.00001224664],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965771,0.001159187,0.0001371096,0.0001386872,0.00002149378,0.000004536401,0.0005014539,0.000004829444,0.001455585],"genre_scores_gemma":[0.9993261,0.00008285516,0.00002786439,0.00003025107,0.00001209984,0.000001249106,0.0001530135,0.000002779227,0.0003638302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004691071,"threshold_uncertainty_score":0.01569319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145409028837106,"score_gpt":0.3395445616480425,"score_spread":0.3180904713596714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}