{"id":"W4308775132","doi":"10.1007/s00280-022-04491-7","title":"Fluoropyrimidine-associated toxicity and DPYD variants c.85T>C, c.496A>G, and c.1236G>A: impact of haplotype","year":2022,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"DPYD; Dihydropyrimidine dehydrogenase; Capecitabine; Toxicity; Haplotype; Internal medicine; Medicine; Pharmacogenetics; Linkage disequilibrium; Dosing; Fluorouracil; Genotyping; Pharmacology; Genotype; Thymidylate synthase; Oncology; Chemotherapy; Biology; Cancer; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001694262,0.0002452219,0.0006159234,0.00008619975,0.0002565233,0.000007874335,0.00005747356,0.00008052956,0.002043153],"category_scores_gemma":[0.00001106955,0.0002022354,0.00008525504,0.0002012312,0.0002248098,0.00005200828,0.0001058532,0.0002064696,3.934385e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002888857,"about_ca_system_score_gemma":0.0001682744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000383656,"about_ca_topic_score_gemma":0.00006250282,"domain_scores_codex":[0.9988441,0.0000888302,0.0002368312,0.0003721967,0.0001473891,0.0003106834],"domain_scores_gemma":[0.9994357,0.00009768773,0.0001440142,0.00009356684,0.00007689368,0.0001521083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01045344,0.001459719,0.1881331,0.0002473521,0.005394092,0.0001055759,0.005130721,0.00002459133,0.6737688,0.00006361436,0.0234653,0.09175365],"study_design_scores_gemma":[0.02888904,0.008480694,0.8924464,0.00006110851,0.001230867,0.0001666594,0.000229423,0.001199359,0.04726728,0.0003697969,0.01905408,0.0006052748],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710111,0.02563079,0.000002555047,0.0018095,0.0002907212,0.0004749227,0.0001976171,0.00003610298,0.0005467043],"genre_scores_gemma":[0.9744318,0.02313378,0.00002868314,0.001571843,0.000124849,0.0001405265,0.00001549346,0.00002916812,0.0005238199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7043133,"threshold_uncertainty_score":0.9988691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145409028837106,"score_gpt":0.3395445616480425,"score_spread":0.3180904713596714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}