{"id":"W4308804792","doi":"10.1016/j.ymthe.2022.11.002","title":"AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Western University","funders":"International Society for Neurochemistry; Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional; Consejo Nacional de Investigaciones Científicas y Técnicas; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Alzheimer Society; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Northwestern University","keywords":"Hippocampal formation; Long-term potentiation; Antibody; Alzheimer's disease; Neuroscience; Amyloid (mycology); Chemistry; Cell biology; Biology; Immunology; Molecular biology; Medicine; Biochemistry; Disease; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404672,0.0005833363,0.0004762173,0.0005703891,0.0002979014,0.000449384,0.0005439392,0.0008037527,0.001418167],"category_scores_gemma":[0.0001328562,0.0002375021,0.0003853916,0.0002679364,0.0003742397,0.0004422537,0.0001913142,0.001363244,0.0005373831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004691431,"about_ca_system_score_gemma":0.0004799505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003491752,"about_ca_topic_score_gemma":0.003172913,"domain_scores_codex":[0.9998065,0.00001268953,0.00002169327,0.00004395082,0.00004857272,0.00006662153],"domain_scores_gemma":[0.9998589,0.0000114778,0.00003177446,0.00001610294,0.00003094896,0.00005070561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643563,0.00008567196,0.00008407704,0.00003175917,0.00001399038,0.00005879523,0.00002438351,0.000048354,0.9978828,0.0002221638,0.0001213614,0.001262169],"study_design_scores_gemma":[0.00006455705,0.000462073,0.00233897,0.00001364673,0.00004825841,0.0003198076,0.00006411047,0.001216482,0.9928281,0.0001726171,0.00246368,0.000007772189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886727,0.001225374,0.006135287,0.0002728438,0.0001630344,0.00006365075,0.0009658694,0.0003028169,0.002198544],"genre_scores_gemma":[0.9808123,0.001548058,0.005141061,0.0001361203,0.00003663877,0.00006352523,0.001245044,0.00007832284,0.01093896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491752,"threshold_uncertainty_score":0.006942868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0331831704004565,"score_gpt":0.3319054602965704,"score_spread":0.2987222898961139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}