{"id":"W4308821092","doi":"10.21203/rs.3.rs-2231253/v1","title":"Aβ plaque deposition and microgliosis following Aβ seeding in AppNL-G-F mice is regionally distinct","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"RIKEN Brain Science Institute; RIKEN; Canadian Institutes of Health Research","keywords":"Substantia nigra; Neuroscience; Pathology; Seeding; Cholinergic; Biology; Psychology; Medicine; Disease; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433943,0.0006214823,0.0003130489,0.0008110208,0.0002430048,0.000385398,0.0002506055,0.0006483831,0.001606271],"category_scores_gemma":[0.0001652347,0.000289676,0.0003943115,0.0001821119,0.0004940392,0.0003723595,0.0002895971,0.0009932966,0.0004947812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053751,"about_ca_system_score_gemma":0.0001690762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007299373,"about_ca_topic_score_gemma":0.001101537,"domain_scores_codex":[0.9997943,0.00002110134,0.00002283797,0.00006587408,0.00004549238,0.00005036821],"domain_scores_gemma":[0.9995286,0.00004402644,0.0001911903,0.00004091352,0.00004043439,0.0001547664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000424804,0.0001173935,0.000370174,0.00002127049,0.000007065669,0.0001142761,0.00003442276,0.0000189223,0.9983135,0.00005135423,0.00002892772,0.0004978303],"study_design_scores_gemma":[0.00009739985,0.00201709,0.03531832,0.00002706686,0.00005608324,0.001393442,0.0001443115,0.000647706,0.9587802,0.0002400419,0.001258903,0.00001939982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961262,0.0005386568,0.001457544,0.00007221761,0.00002391849,0.00002999465,0.0004087744,0.00009958315,0.001243018],"genre_scores_gemma":[0.9880183,0.0006159051,0.004073529,0.0000900192,0.00002260745,0.00008672869,0.0007532627,0.0000816638,0.006258021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606271,"threshold_uncertainty_score":0.005373538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06663068355838007,"score_gpt":0.404987203318671,"score_spread":0.3383565197602909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}