{"id":"W4308831840","doi":"10.1101/2022.11.11.515814","title":"The chemorepellent, SLIT2, bolsters innate immunity against <i>Staphylococcus aureus</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Mount Sinai Hospital; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Canada Research Chairs; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Svenska Läkaresällskapet; Stiftelsen Blanceflor Boncompagni Ludovisi, född Bildt; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Staphylococcus aureus; Innate immune system; Chemotaxis; Microbiology; Degranulation; NADPH oxidase; Biology; Immunology; Immune system; Leukocidin; Antimicrobial peptides; Cell biology; Antimicrobial; Reactive oxygen species; Bacteria; Methicillin-resistant Staphylococcus aureus; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586784,0.0002919902,0.000186245,0.0002081437,0.0002747728,0.0006607125,0.0001492677,0.0004062029,0.01371588],"category_scores_gemma":[0.0001918373,0.00008746854,0.0001864943,0.0001153163,0.0001977508,0.0003402596,0.0002583631,0.0003351849,0.005303731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883784,"about_ca_system_score_gemma":0.0002313875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002984677,"about_ca_topic_score_gemma":0.0006172174,"domain_scores_codex":[0.9999151,0.000008411272,0.000003590616,0.00001611276,0.00004687691,0.000009935087],"domain_scores_gemma":[0.9999372,0.000008669208,0.00001124458,0.000006173675,0.00001712259,0.00001963997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003630688,0.00007440305,0.001401445,0.000491255,0.00002659676,0.0005650796,0.00006278955,0.0003794043,0.8380517,0.006006198,0.1220925,0.03048561],"study_design_scores_gemma":[0.00006014264,0.000274529,0.01387533,0.0001008912,0.00004731332,0.002064073,0.0001346793,0.005569624,0.654211,0.003540616,0.3200936,0.00002802564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6253017,0.02900457,0.04521511,0.03365147,0.02987624,0.0002448764,0.01140553,0.008199833,0.2171007],"genre_scores_gemma":[0.729287,0.00784531,0.01012937,0.00173803,0.004600686,0.0000518768,0.004772433,0.0007240801,0.2408512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01371588,"threshold_uncertainty_score":0.04588425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229976683426357,"score_gpt":0.2134334939201414,"score_spread":0.2011337270858778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}