{"id":"W4308834973","doi":"10.1007/s40257-022-00739-3","title":"Effect of Roflumilast Cream (ARQ-151) on Itch and Itch-Related Sleep Loss in Adults with Chronic Plaque Psoriasis: Patient-Reported Itch Outcomes of a Phase 2b Trial","year":2022,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research","funders":"","keywords":"Medicine; Roflumilast; Psoriasis; Psoriasis Area and Severity Index; Eczema Area and Severity Index; Erythema; Dermatology; Dermatology Life Quality Index; Severity of illness; Body surface area; Dose-ranging study; Randomized controlled trial; Post-hoc analysis; Physical therapy; Internal medicine; Atopic dermatitis; Placebo; Double blind; Pathology; COPD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002083781,0.001059433,0.001931608,0.0003237975,0.0003496807,0.0007181211,0.0006242918,0.001297736,0.005334568],"category_scores_gemma":[0.001568626,0.0003838115,0.001861786,0.0002824447,0.0004704565,0.0007462363,0.0002703773,0.001999481,0.0009050459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004334133,"about_ca_system_score_gemma":0.0006152792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007270939,"about_ca_topic_score_gemma":0.001659638,"domain_scores_codex":[0.9994048,0.0003122358,0.00005208572,0.00009357055,0.00006191422,0.00007545247],"domain_scores_gemma":[0.9990816,0.0002572433,0.0002769013,0.00006625654,0.00008980339,0.0002282203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9044321,0.01330833,0.003734447,0.002515521,0.002985176,0.00008729647,0.00010463,0.0005450497,0.00776398,0.0001262396,0.002929411,0.06146766],"study_design_scores_gemma":[0.8986009,0.09000378,0.008656763,0.00008889773,0.0008448974,0.00008869475,0.00002461309,0.000328396,0.0004006839,0.00008169191,0.0008628912,0.0000179014],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750041,0.0142295,0.000435866,0.0008964498,0.0002805617,0.003491941,0.001928603,0.0001368132,0.003596181],"genre_scores_gemma":[0.9856496,0.004425829,0.000906647,0.001323648,0.0003660339,0.003788393,0.001697536,0.00002215385,0.001820006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005334568,"threshold_uncertainty_score":0.01784587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184073923197095,"score_gpt":0.3098236362632958,"score_spread":0.2979828970313249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}