{"id":"W4308834973","doi":"10.1007/s40257-022-00739-3","title":"Effect of Roflumilast Cream (ARQ-151) on Itch and Itch-Related Sleep Loss in Adults with Chronic Plaque Psoriasis: Patient-Reported Itch Outcomes of a Phase 2b Trial","year":2022,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research","funders":"","keywords":"Medicine; Roflumilast; Psoriasis; Psoriasis Area and Severity Index; Eczema Area and Severity Index; Erythema; Dermatology; Dermatology Life Quality Index; Severity of illness; Body surface area; Dose-ranging study; Randomized controlled trial; Post-hoc analysis; Physical therapy; Internal medicine; Atopic dermatitis; Placebo; Double blind; Pathology; COPD","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001226673,0.0003801913,0.002878726,0.0004313293,0.0001030927,0.00000433171,0.0003740784,0.000274677,0.0001745956],"category_scores_gemma":[0.0007326278,0.000271625,0.0004869961,0.000491358,0.001012827,0.00008092773,0.0001269581,0.0009437828,0.00000682973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006665466,"about_ca_system_score_gemma":0.0003468807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001621209,"about_ca_topic_score_gemma":0.00004111376,"domain_scores_codex":[0.9923365,0.003484558,0.00309986,0.0004271765,0.0002016565,0.0004502409],"domain_scores_gemma":[0.9915325,0.004216567,0.003623615,0.0003783105,0.0001458099,0.0001031904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2651622,0.004436582,0.5885671,0.00005729781,0.00332985,0.001010525,0.0006582483,0.00004776585,0.0007174512,0.00003202803,0.0001388503,0.1358421],"study_design_scores_gemma":[0.6025828,0.170756,0.1848008,0.0005318514,0.00296861,0.009296326,0.001453494,0.00003945656,0.02480268,0.0000626068,0.001838153,0.0008673282],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996357,0.001100741,0.000007012892,0.0004878152,0.001290393,0.0006260084,0.00006465868,0.00001543528,0.00005092459],"genre_scores_gemma":[0.9993088,0.000358798,0.00003277515,0.0001133785,0.00003701089,0.00005700012,0.00004522603,0.00003061478,0.00001640177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4037663,"threshold_uncertainty_score":0.9999736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184073923197095,"score_gpt":0.3098236362632958,"score_spread":0.2979828970313249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}