{"id":"W4308844496","doi":"10.1101/2022.11.11.516204","title":"Core Defense Hotspots within <i>Pseudomonas aeruginosa</i> are a consistent and rich source of anti-phage defense systems","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation","keywords":"Biology; Genome; Pseudomonas aeruginosa; CRISPR; Computational biology; Phage display; Mobile genetic elements; Genetics; Bacteriophage; Gene; Immune system; Bacteria; Escherichia coli; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931551,0.0003713913,0.0003860879,0.0008922852,0.0004748436,0.0006939162,0.0002271694,0.0002956999,0.001580219],"category_scores_gemma":[0.0004971481,0.0001989479,0.0003969091,0.0009012256,0.0002288595,0.0004071601,0.0005020878,0.0003193107,0.0003387648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003287428,"about_ca_system_score_gemma":0.0003736325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002716776,"about_ca_topic_score_gemma":0.004888133,"domain_scores_codex":[0.9997783,0.00002979932,0.000009696796,0.0001023271,0.0000458628,0.0000340405],"domain_scores_gemma":[0.999736,0.0000762981,0.00009641277,0.00002600357,0.00003226459,0.00003301057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004762756,0.0001272307,0.156155,0.000964407,0.0003307435,0.0004028083,0.0002829483,0.01875161,0.7573962,0.001719986,0.002555789,0.06083705],"study_design_scores_gemma":[0.00006527943,0.0003944001,0.6564478,0.0001317729,0.0003915282,0.00111249,0.0007328152,0.176723,0.1392222,0.006850086,0.01781919,0.0001093767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776783,0.0007322383,0.01477733,0.0001198949,0.00001188475,0.00002979675,0.003491893,0.0008926501,0.002266107],"genre_scores_gemma":[0.9784765,0.0002438757,0.01575355,0.0000652577,0.000007578125,0.00003060936,0.004818283,0.0000760103,0.0005283633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002716776,"threshold_uncertainty_score":0.005401909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966671162654402,"score_gpt":0.2177827808184573,"score_spread":0.1981160691919133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}