{"id":"W4308868384","doi":"10.3389/fphys.2022.1009320","title":"Modelling of p-tyramine transport across human intestinal epithelial cells predicts the presence of additional transporters","year":2022,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland","keywords":"Transporter; Cell biology; Tyramine; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003844064,0.0007279564,0.0009265984,0.0003488879,0.000361728,0.001261035,0.0008597981,0.002523783,0.001130068],"category_scores_gemma":[0.001266064,0.0004502424,0.001401209,0.0004425755,0.000412639,0.0006390678,0.000534974,0.0007592494,0.0003600034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001311063,"about_ca_system_score_gemma":0.0009936402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02455486,"about_ca_topic_score_gemma":0.008439172,"domain_scores_codex":[0.999803,0.00004511676,0.00001625367,0.00005573132,0.00003869887,0.00004116595],"domain_scores_gemma":[0.999445,0.0003173501,0.00005646545,0.0000232087,0.0001360385,0.00002183062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006033766,0.00002681006,0.001211719,0.00009050252,0.00001716944,0.0001128386,0.0000485368,0.9882424,0.007891822,0.0008764167,0.0001242475,0.001297197],"study_design_scores_gemma":[0.000005914301,0.00002302032,0.0002387252,0.000004165082,0.00000832318,0.00001531434,0.00001593598,0.9980634,0.001151838,0.0001760327,0.0002916319,0.000005727261],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8563973,0.001810349,0.1252342,0.0008083101,0.0001254695,0.0001572121,0.001882549,0.0003572724,0.0132274],"genre_scores_gemma":[0.978906,0.000930385,0.01234514,0.0001141588,0.00001808483,0.0002147496,0.0007715579,0.00005545649,0.006644316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02455486,"threshold_uncertainty_score":0.04882383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108462806130343,"score_gpt":0.2233259779273084,"score_spread":0.212479697314274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}