{"id":"W4308896255","doi":"10.1101/2022.11.11.516143","title":"Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Glycan; Biology; HIV vaccine; Antibody; Virology; Affinity maturation; Computational biology; Immunology; Genetics; Glycoprotein; Vaccine trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004531618,0.0003505582,0.0002115095,0.0001636793,0.0001725911,0.0003345001,0.0002750291,0.0003739189,0.002318782],"category_scores_gemma":[0.0002955564,0.0001714989,0.0002378497,0.0000794373,0.0001957841,0.0002544757,0.0001851592,0.0006188441,0.00119856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717408,"about_ca_system_score_gemma":0.0003547847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001427056,"about_ca_topic_score_gemma":0.0002333876,"domain_scores_codex":[0.9998702,0.00003289156,0.000008156293,0.00002004412,0.00005598336,0.00001279342],"domain_scores_gemma":[0.9999025,0.00002500068,0.00002546146,0.00001218711,0.00001980185,0.00001502821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000918369,0.00003402249,0.0001588253,0.0001015289,0.000007878975,0.00007002044,0.00001745225,0.000782736,0.981779,0.002809281,0.001752128,0.01239529],"study_design_scores_gemma":[0.00006224526,0.0004425794,0.0004482604,0.00001412844,0.0000213448,0.0002964027,0.00001468539,0.005576864,0.959775,0.001644448,0.03168871,0.00001532773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5154226,0.00919237,0.4455852,0.005934494,0.002590561,0.0009337155,0.0009726431,0.00224007,0.0171284],"genre_scores_gemma":[0.7284907,0.004205017,0.2414673,0.001583272,0.0003989339,0.0003654924,0.0005856389,0.0003371514,0.02256647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318782,"threshold_uncertainty_score":0.007757068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05909970818030593,"score_gpt":0.3129401477262734,"score_spread":0.2538404395459675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}