{"id":"W4308913774","doi":"10.15252/msb.202110886","title":"Synthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells","year":2022,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Toronto","funders":"Canadian Institutes of Health Research; ETH Zürich Foundation; Canada First Research Excellence Fund; Canada Research Chairs; Royal Academy of Engineering; Banting Research Foundation; Stavros Niarchos Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Toronto; Michael Smith Health Research BC; National Science Foundation","keywords":"Biology; Induced pluripotent stem cell; Cell biology; Stem cell; Computational biology; Gene; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003496238,0.0001713893,0.0002015315,0.000109907,0.0001335048,0.00001747583,0.0001337804,0.00009781926,0.000001777514],"category_scores_gemma":[0.000005959129,0.0001920476,0.00006140613,0.00008070036,0.00003022523,0.00000144807,0.0001480111,0.000112046,6.045832e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004154191,"about_ca_system_score_gemma":0.00002318701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007574633,"about_ca_topic_score_gemma":0.00001730617,"domain_scores_codex":[0.9986727,0.0001832786,0.000281375,0.0004733298,0.00006925684,0.0003200484],"domain_scores_gemma":[0.9995586,0.000007593422,0.00008508901,0.0002595214,0.00002998973,0.00005917956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001724846,0.00002856481,0.000065114,0.0000929991,0.00002064198,0.000009882766,0.00005872243,0.008750926,0.9895641,0.00002326416,0.000004645342,0.001363874],"study_design_scores_gemma":[0.000694125,0.0006737952,0.00004405124,0.00001099296,0.00001079651,0.00003996702,0.0001239657,0.002936565,0.9892566,0.00002447672,0.005951267,0.0002334453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8601988,0.003143054,0.1354539,0.00001006599,0.0002317992,0.00086922,0.00003841972,0.00001477699,0.00003999857],"genre_scores_gemma":[0.9987779,0.00001566055,0.00009019744,0.00002383601,0.00004287649,0.0006596791,0.00003902388,0.00003760999,0.0003132319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1385791,"threshold_uncertainty_score":0.7831476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006967167043624431,"score_gpt":0.2469461917355762,"score_spread":0.2399790246919518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}