{"id":"W4308913774","doi":"10.15252/msb.202110886","title":"Synthetic gene circuits for cell state detection and protein tuning in human pluripotent stem cells","year":2022,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Toronto","funders":"Canadian Institutes of Health Research; ETH Zürich Foundation; Canada First Research Excellence Fund; Canada Research Chairs; Royal Academy of Engineering; Banting Research Foundation; Stavros Niarchos Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Toronto; Michael Smith Health Research BC; National Science Foundation","keywords":"Biology; Induced pluripotent stem cell; Cell biology; Stem cell; Computational biology; Gene; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578897,0.0001935021,0.0001280855,0.0001044231,0.00008455675,0.0002739436,0.0002964946,0.0001919043,0.000630515],"category_scores_gemma":[0.0002913642,0.0001095288,0.0001252466,0.00009134606,0.0002687407,0.0002042758,0.0001960192,0.0002928947,0.0001366932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000324396,"about_ca_system_score_gemma":0.0001642209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001673517,"about_ca_topic_score_gemma":0.0003159763,"domain_scores_codex":[0.999853,0.0000186622,0.000009174802,0.00003380422,0.00007078404,0.00001455702],"domain_scores_gemma":[0.9999119,0.00002691277,0.00003211482,0.000008521317,0.00001193161,0.000008652783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002137523,0.00001508051,0.00009435188,0.00003256027,0.000003550602,0.00002564228,0.0000149476,0.002149241,0.9907618,0.002304185,0.00008382152,0.004493438],"study_design_scores_gemma":[0.00000943023,0.00009683559,0.0002094104,0.000002644157,0.000005884905,0.00003622231,0.00000557118,0.01402844,0.9822744,0.0004417659,0.002883937,0.000005422804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7584509,0.0005888729,0.2326142,0.0003303899,0.0001533671,0.000145653,0.0002929975,0.0009020335,0.006521662],"genre_scores_gemma":[0.9549316,0.0002348272,0.04200674,0.0001172317,0.00001220418,0.0000932742,0.00009207409,0.00007168904,0.002440267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000630515,"threshold_uncertainty_score":0.002353668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006967167043624431,"score_gpt":0.2469461917355762,"score_spread":0.2399790246919518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}