{"id":"W4308949824","doi":"10.1101/2022.11.11.516125","title":"Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Avidity; Antibody; Monoclonal antibody; Neutralization; Epitope; Virology; Neutralizing antibody; Potency; Chemistry; Biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004827176,0.0005659668,0.000227367,0.0003484052,0.00009420005,0.0003724727,0.00032225,0.0003766007,0.001464502],"category_scores_gemma":[0.0003187878,0.0001773292,0.0002069145,0.0001955921,0.0001613312,0.0002507934,0.0002439677,0.0005651346,0.0003822551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004511328,"about_ca_system_score_gemma":0.000145372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007716509,"about_ca_topic_score_gemma":0.001061454,"domain_scores_codex":[0.999585,0.00007703947,0.00003523933,0.0000713863,0.0001287107,0.0001026927],"domain_scores_gemma":[0.9998185,0.00003927618,0.00003181714,0.00002381662,0.00005091192,0.00003569497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000357602,0.00004046454,0.0001664494,0.00001470207,0.000007293108,0.000005809069,0.000004327436,0.0001306989,0.9973211,0.00005661737,0.00003332521,0.002183519],"study_design_scores_gemma":[0.00001364753,0.0004668522,0.001740817,0.000005275133,0.00002176689,0.00006653983,0.000007348943,0.001362518,0.9946986,0.00002967635,0.001582824,0.000004104554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852481,0.001465438,0.009961889,0.00008715918,0.0000334025,0.00008210759,0.000174539,0.0001462028,0.002801158],"genre_scores_gemma":[0.993368,0.0003051923,0.004681317,0.00009798491,0.00001316261,0.0000320221,0.0002064583,0.00002404675,0.001271912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464502,"threshold_uncertainty_score":0.004899323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03997712872422553,"score_gpt":0.3083381857604767,"score_spread":0.2683610570362512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}