{"id":"W4308951928","doi":"10.1371/journal.pgen.1010495","title":"Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; McGill University; Jewish General Hospital","funders":"Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación; Cole Foundation; Cancer Research Society","keywords":"Biology; RAD51; Genetics; Homologous recombination; DNA repair; Genome instability; Genome; DNA damage; Synthetic lethality; Computational biology; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005379724,0.0001403157,0.0002618337,0.00002377079,0.0001328348,0.00001307585,0.0002931329,0.00008240632,0.00001832808],"category_scores_gemma":[0.0004584908,0.0001097164,0.0001627904,0.00007035798,0.0001039315,0.000001775072,0.000509074,0.0001403781,6.357702e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003489153,"about_ca_system_score_gemma":0.0001309169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.933639e-7,"about_ca_topic_score_gemma":0.000003027197,"domain_scores_codex":[0.9983607,0.0002385879,0.0005842734,0.0003621857,0.0002598646,0.0001943764],"domain_scores_gemma":[0.998956,0.0001063719,0.0002700636,0.0004892889,0.0001189299,0.00005938092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494284,0.0002212703,0.002051023,0.001690637,0.0001717938,4.566759e-7,0.0001750697,0.00008256665,0.9952158,0.0001614432,0.00003592921,0.0000446322],"study_design_scores_gemma":[0.003434956,0.006420424,0.01364068,0.0005488863,0.0007124494,0.0001092694,0.002517578,0.02925036,0.9325843,0.003843711,0.005822634,0.00111471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956819,0.0004285689,0.00202055,0.0002010479,0.0002343167,0.001264288,0.0001146663,0.00001025134,0.0000443904],"genre_scores_gemma":[0.9961917,0.00002074698,0.003032075,0.0001643874,0.00007739779,0.000265228,0.00004166351,0.00002604417,0.0001807734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06263141,"threshold_uncertainty_score":0.4474106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0287149547982906,"score_gpt":0.2465887140890733,"score_spread":0.2178737592907828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}