{"id":"W4308951928","doi":"10.1371/journal.pgen.1010495","title":"Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; McGill University; Jewish General Hospital","funders":"Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación; Cole Foundation; Cancer Research Society","keywords":"Biology; RAD51; Genetics; Homologous recombination; DNA repair; Genome instability; Genome; DNA damage; Synthetic lethality; Computational biology; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337435,0.0003786812,0.0002483167,0.0005706762,0.0002592588,0.0003834848,0.0001992382,0.0002806181,0.001957253],"category_scores_gemma":[0.0001368389,0.0001428429,0.0003315089,0.000311093,0.0001772139,0.0002434391,0.0004048659,0.0004166446,0.001082511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002721717,"about_ca_system_score_gemma":0.0002204684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006323915,"about_ca_topic_score_gemma":0.001119192,"domain_scores_codex":[0.9998746,0.00001368006,0.000009021003,0.00004232499,0.00003182597,0.00002855937],"domain_scores_gemma":[0.9999034,0.00001522326,0.00002698726,0.00001628506,0.0000129503,0.00002509894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009419433,0.000009305916,0.001697392,0.00004064688,0.000006664352,0.0001171871,0.00001960324,0.00007813648,0.9951915,0.0002360226,0.00006316658,0.002446234],"study_design_scores_gemma":[0.00001662146,0.0001931005,0.1005357,0.00002930584,0.00007005837,0.001566445,0.0001987748,0.003518284,0.8743871,0.0005445222,0.01892001,0.00002014874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796249,0.003246513,0.01296504,0.000141431,0.00002992905,0.00003997272,0.001638863,0.0001562558,0.002157192],"genre_scores_gemma":[0.9804854,0.001377911,0.01019414,0.00009916721,0.00001117038,0.00004086986,0.00287595,0.00005647737,0.004858798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957253,"threshold_uncertainty_score":0.006547689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0287149547982906,"score_gpt":0.2465887140890733,"score_spread":0.2178737592907828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}