{"id":"W4308956492","doi":"10.1097/fpc.0000000000000486","title":"Impact of organic anion transporting polypeptide, P-glycoprotein, and breast cancer resistance protein transporters on observed tamoxifen and endoxifen concentration and adverse effects","year":2022,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"Tamoxifen; Abcg2; SLCO1B1; Pharmacology; CYP2D6; Breast cancer; Organic anion-transporting polypeptide; Transporter; Efflux; Antiestrogen; Medicine; Chemistry; Internal medicine; Pharmacogenetics; Cancer; ATP-binding cassette transporter; Genotype; Gene; Metabolism; Biochemistry; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004238044,0.0001599328,0.000280892,0.0002385201,0.0001726004,0.0003602185,0.0001116077,0.0002249228,0.001444609],"category_scores_gemma":[0.001506009,0.00008416008,0.00027603,0.0004086921,0.0001955143,0.0001746737,0.0001415782,0.0002778839,0.0001615021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140487,"about_ca_system_score_gemma":0.0001577777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151901,"about_ca_topic_score_gemma":0.001857214,"domain_scores_codex":[0.9993679,0.000195964,0.00006266134,0.0001585159,0.0001541105,0.00006077169],"domain_scores_gemma":[0.9985827,0.0004357417,0.0006735513,0.00006570797,0.0001269821,0.000115263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001256232,0.00005249907,0.9813396,0.00002832847,0.0001589847,0.000276001,0.00006192849,0.00008260554,0.01241867,0.00002090447,0.00004982752,0.004254364],"study_design_scores_gemma":[0.00001037459,0.0003909718,0.9965718,0.000004272295,0.00009175552,0.0006469002,0.00005366767,0.0002069599,0.001776944,0.00001831454,0.0002250805,0.000002962543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999078,0.0004026345,0.00007540212,0.00003178891,0.000002696504,0.000003013555,0.0001506126,0.000002327518,0.0002534627],"genre_scores_gemma":[0.9997011,0.00005017913,0.00005261481,0.00001409615,0.000002390041,0.000001881006,0.00007945236,0.000001288512,0.00009699603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444609,"threshold_uncertainty_score":0.004832685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140252406636221,"score_gpt":0.2528596884057164,"score_spread":0.2414571643393542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}