{"id":"W4308956492","doi":"10.1097/fpc.0000000000000486","title":"Impact of organic anion transporting polypeptide, P-glycoprotein, and breast cancer resistance protein transporters on observed tamoxifen and endoxifen concentration and adverse effects","year":2022,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"Tamoxifen; Abcg2; SLCO1B1; Pharmacology; CYP2D6; Breast cancer; Organic anion-transporting polypeptide; Transporter; Efflux; Antiestrogen; Medicine; Chemistry; Internal medicine; Pharmacogenetics; Cancer; ATP-binding cassette transporter; Genotype; Gene; Metabolism; Biochemistry; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913252,0.0002442048,0.0003755025,0.00004973716,0.0001931542,0.00001206682,0.00004934996,0.00005449624,0.00004624492],"category_scores_gemma":[0.000002625598,0.0002257965,0.00006454181,0.0001231888,0.0001149523,0.00004854723,0.00001643109,0.0001935777,8.260506e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007370176,"about_ca_system_score_gemma":0.0001212182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007382318,"about_ca_topic_score_gemma":0.0000681062,"domain_scores_codex":[0.9987368,0.00004128581,0.0003570506,0.0003901575,0.0002071365,0.0002675653],"domain_scores_gemma":[0.999401,0.00002120897,0.0001857446,0.000120381,0.00004644725,0.000225237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001951684,0.00009316466,0.08559221,0.0005850681,0.0001529656,0.00005212573,0.001161035,0.00004892909,0.9057471,0.00002901582,0.000004522549,0.004582171],"study_design_scores_gemma":[0.008058931,0.0008722291,0.727137,0.0002963529,0.0006366765,0.00007646171,0.0002210588,0.0005432068,0.2613663,0.0001273443,0.0002203861,0.0004441227],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992557,0.005403657,0.00009512428,0.0002485285,0.00005847446,0.001266398,0.00032646,0.00001999874,0.00002430314],"genre_scores_gemma":[0.9960313,0.003177519,0.0003949784,0.000114198,0.00005156321,0.00006761905,0.00004622053,0.00004225625,0.00007428722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6443809,"threshold_uncertainty_score":0.9207714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140252406636221,"score_gpt":0.2528596884057164,"score_spread":0.2414571643393542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}