{"id":"W4308963718","doi":"10.1038/s41598-022-23828-z","title":"Plant-produced recombinant cytokines IL-37b and IL-38 modulate inflammatory response from stimulated human PBMCs","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Agriculture and Agri-Food Canada","keywords":"Peripheral blood mononuclear cell; Phytohaemagglutinin; Recombinant DNA; Lipopolysaccharide; Ex vivo; In vivo; Proinflammatory cytokine; Inflammation; Interleukin; Secretion; Cytokine; Biology; Immunology; Biotechnology; In vitro; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672258,0.0002914267,0.000181011,0.0001316684,0.00008965241,0.0002173636,0.0001175777,0.0002029134,0.001622833],"category_scores_gemma":[0.00009331405,0.00008084759,0.0001847643,0.000109965,0.0001660804,0.0001628303,0.0001451797,0.0006520744,0.0004821123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635428,"about_ca_system_score_gemma":0.0001471377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001623311,"about_ca_topic_score_gemma":0.0003203029,"domain_scores_codex":[0.9998851,0.00002409892,0.000009495215,0.00002530403,0.00003661809,0.00001933502],"domain_scores_gemma":[0.9999448,0.00001693287,0.00001365197,0.00000889216,0.000006602662,0.000009143611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000229766,0.00000893099,0.00002463215,0.00001369537,7.852202e-7,0.000008026336,0.000004849757,0.0000153715,0.9996262,0.00001513702,0.000006253528,0.000253041],"study_design_scores_gemma":[0.000009792499,0.0001944551,0.001000359,0.000003881481,0.000007466455,0.0001036235,0.0000181684,0.0002862795,0.996716,0.00003908141,0.001618889,0.0000021158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824718,0.002197593,0.01210006,0.0002116984,0.00005041328,0.0001030042,0.0007934585,0.0001267879,0.001945368],"genre_scores_gemma":[0.9836389,0.00117828,0.01119389,0.00009079628,0.00001577591,0.00009320011,0.0009098198,0.00002313249,0.002856219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622833,"threshold_uncertainty_score":0.00542891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383479524771921,"score_gpt":0.2397351096356307,"score_spread":0.2259003143879114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}