{"id":"W4308963718","doi":"10.1038/s41598-022-23828-z","title":"Plant-produced recombinant cytokines IL-37b and IL-38 modulate inflammatory response from stimulated human PBMCs","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Agriculture and Agri-Food Canada","keywords":"Peripheral blood mononuclear cell; Phytohaemagglutinin; Recombinant DNA; Lipopolysaccharide; Ex vivo; In vivo; Proinflammatory cytokine; Inflammation; Interleukin; Secretion; Cytokine; Biology; Immunology; Biotechnology; In vitro; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009133552,0.0001619974,0.0001579684,0.00008248164,0.0008183183,0.00009805405,0.0001775463,0.00007031486,0.00008493735],"category_scores_gemma":[0.0000475031,0.0001583431,0.00006551872,0.0001639586,0.0001495683,0.000007382141,0.0002091493,0.0001249156,0.000003913182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001935133,"about_ca_system_score_gemma":0.0001245658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004975922,"about_ca_topic_score_gemma":0.00003644175,"domain_scores_codex":[0.9980133,0.0001117635,0.0004061186,0.0009455264,0.0002636692,0.0002595811],"domain_scores_gemma":[0.9986977,0.00001599044,0.0001990314,0.0009192927,0.00005649707,0.0001114692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001428719,0.00006572573,0.00264452,0.000004968022,0.00003303348,0.0001208692,0.0001221438,0.0002901017,0.9886759,0.00001200069,0.007641297,0.0002465547],"study_design_scores_gemma":[0.0005212972,0.000128955,0.03221061,0.00001272148,0.00003163241,0.0003380362,0.0001069367,0.0001719083,0.5145095,0.001833285,0.4497297,0.0004054476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973829,0.000184192,0.0000264263,0.000175962,0.001453435,0.0003110035,0.0003687467,0.00004118423,0.00005616384],"genre_scores_gemma":[0.9951327,0.00001295461,0.00009300584,0.00003449605,0.00006155836,0.00006467665,0.001948041,0.00002162942,0.002630897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4741664,"threshold_uncertainty_score":0.6457043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383479524771921,"score_gpt":0.2397351096356307,"score_spread":0.2259003143879114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}