{"id":"W4308966607","doi":"10.21203/rs.3.rs-2136604/v1","title":"Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Canadian Science Centre for Human and Animal Health","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; St. Jude Children's Research Hospital","keywords":"Reassortment; Influenza A virus subtype H5N1; Clade; Biology; Virology; Lineage (genetic); Highly pathogenic; Viral evolution; Virus; Influenza A virus; Pandemic; Phylogenetics; Gene; Genetics; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Genome; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001397726,0.0005552148,0.001247557,0.002415366,0.0003264353,0.00008732745,0.0009159207,0.0002670874,0.004026675],"category_scores_gemma":[0.003866784,0.0005133893,0.0005645374,0.001773928,0.0008302236,0.0001437081,0.009145848,0.00388379,0.0005602728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002551492,"about_ca_system_score_gemma":0.001464742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004389631,"about_ca_topic_score_gemma":0.0003901458,"domain_scores_codex":[0.9910043,0.001054769,0.001023312,0.001238822,0.004175566,0.001503221],"domain_scores_gemma":[0.9945347,0.0005752989,0.0002197616,0.001874757,0.002152816,0.0006426913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02541336,0.002686934,0.8279236,0.01344714,0.002350556,0.001063354,0.01975039,0.0009595303,0.007337096,0.0001061643,0.04472236,0.05423953],"study_design_scores_gemma":[0.001767454,0.003398121,0.5434849,0.002202803,0.0001048518,0.000009862658,0.005161337,0.0001295741,0.001367013,0.0001106476,0.4416494,0.0006140125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771593,0.01133217,0.0000805423,0.0007099454,0.0002953301,0.00443907,0.001713333,0.0001496522,0.004120697],"genre_scores_gemma":[0.9924152,0.001079858,0.0007438149,0.0007572091,0.0005072839,0.003380713,0.0001755487,0.0001405743,0.0007997392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.396927,"threshold_uncertainty_score":0.9997318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1356170006133975,"score_gpt":0.4549720052315412,"score_spread":0.3193550046181437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}