{"id":"W4308969753","doi":"10.3390/biomedicines10112913","title":"Necroptosis Blockade Potentiates the Neuroprotective Effect of Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation de l'Hôpital de Montréal pour enfants; Fondation des Etoiles; Région Auvergne-Rhône-Alpes; Fondation Brain Canada","keywords":"Neuroprotection; Necroptosis; Hypothermia; Medicine; Blockade; Encephalopathy; Ischemia; Hypoxia (environmental); Pharmacology; Hypoxic Ischemic Encephalopathy; Programmed cell death; Neuroscience; Anesthesia; Internal medicine; Receptor; Biology; Apoptosis; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004841634,0.0002031045,0.000444241,0.0002691065,0.0001225053,0.000003187412,0.0002498419,0.00005704877,0.0001861921],"category_scores_gemma":[0.0002406464,0.000121696,0.0001277288,0.0008038898,0.0004381194,0.00003501686,0.0002290235,0.0003926115,0.00001058056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005025898,"about_ca_system_score_gemma":0.00004918703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001545195,"about_ca_topic_score_gemma":0.000003296888,"domain_scores_codex":[0.99844,0.0002198472,0.0003319528,0.0003340251,0.0003878973,0.0002862454],"domain_scores_gemma":[0.999115,0.0003244375,0.0001333187,0.0003209798,0.00003614845,0.00007004257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0012195,0.0001022266,0.02763276,0.0001661875,0.00005804774,0.0005468872,0.001461603,0.000006315347,0.9136663,0.00001534286,0.0003109318,0.05481387],"study_design_scores_gemma":[0.01139506,0.01100119,0.3100908,0.0002524551,0.0004084197,0.004909371,0.003844086,0.0003735942,0.6260191,0.000355346,0.0307839,0.0005667431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925848,0.003217724,0.00001966634,0.002422616,0.0003565147,0.0007529972,0.00003236999,0.00004280865,0.0005705034],"genre_scores_gemma":[0.998719,0.00004068492,0.00005146636,0.0004682682,0.0001523204,0.0001874,0.00002240852,0.00002665676,0.0003317752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2876472,"threshold_uncertainty_score":0.496262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005820853936935145,"score_gpt":0.2279561431778406,"score_spread":0.2221352892409054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}