{"id":"W4308969753","doi":"10.3390/biomedicines10112913","title":"Necroptosis Blockade Potentiates the Neuroprotective Effect of Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation de l'Hôpital de Montréal pour enfants; Fondation des Etoiles; Région Auvergne-Rhône-Alpes; Fondation Brain Canada","keywords":"Neuroprotection; Necroptosis; Hypothermia; Medicine; Blockade; Encephalopathy; Ischemia; Hypoxia (environmental); Pharmacology; Hypoxic Ischemic Encephalopathy; Programmed cell death; Neuroscience; Anesthesia; Internal medicine; Receptor; Biology; Apoptosis; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002040754,0.0003253831,0.0005551735,0.0002343536,0.0001285703,0.0002009168,0.0002088946,0.0002321304,0.001762951],"category_scores_gemma":[0.0002066706,0.0001096599,0.000247359,0.0001389151,0.0002233444,0.0002993277,0.0002348513,0.0007364601,0.000251828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197139,"about_ca_system_score_gemma":0.00028542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004997567,"about_ca_topic_score_gemma":0.001355122,"domain_scores_codex":[0.9999014,0.00002993265,0.00001421519,0.00001028151,0.00001304095,0.00003116177],"domain_scores_gemma":[0.9999284,0.00001409469,0.00001237594,0.000007922083,0.000008671554,0.00002852579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006723256,0.001122608,0.0004327251,0.000495561,0.00007227494,0.0002842881,0.00008646945,0.0003500512,0.9753841,0.0001648016,0.0003484286,0.01453544],"study_design_scores_gemma":[0.0005338949,0.01765855,0.01282477,0.000110644,0.0001659817,0.0006462717,0.0001088867,0.001124701,0.9633403,0.0001588396,0.003311229,0.0000160141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930298,0.004519871,0.0004994109,0.0001089292,0.00007305596,0.00005022255,0.0001589835,0.00004964,0.001510128],"genre_scores_gemma":[0.9936451,0.004192943,0.0007488807,0.00007105446,0.00004156326,0.00006006277,0.0003234943,0.000008247757,0.0009087549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762951,"threshold_uncertainty_score":0.005897701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005820853936935145,"score_gpt":0.2279561431778406,"score_spread":0.2221352892409054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}