{"id":"W4308970080","doi":"10.3390/applmicrobiol2040071","title":"Globally Disseminated Multidrug Resistance Plasmids Revealed by Complete Assembly of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Genomes from Diarrheal Disease in Botswana","year":2022,"lang":"en","type":"article","venue":"Applied Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Natural Sciences and Engineering Research Council of Canada; Alliance de recherche numérique du Canada; Saskatchewan Health Research Foundation; University of Regina; Simon Fraser University; National Science Foundation","keywords":"Plasmid; Biology; Antibiotic resistance; Klebsiella pneumoniae; Horizontal gene transfer; Escherichia coli; Multiple drug resistance; Microbiology; Gene; Genome; Genetics; Resistome; Drug resistance; Virology; Antibiotics; Mobile genetic elements","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003447174,0.0003931866,0.0006106158,0.00007204789,0.00018966,0.00002249184,0.0005721119,0.0001962843,0.00003779425],"category_scores_gemma":[0.00006093081,0.0004280758,0.00009092245,0.0002197732,0.000449356,0.000005529048,0.0005676401,0.0002708778,0.000003761834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080891,"about_ca_system_score_gemma":0.000142003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002241296,"about_ca_topic_score_gemma":0.000551571,"domain_scores_codex":[0.997307,0.0003073411,0.0007055551,0.0009958645,0.0001213337,0.0005628913],"domain_scores_gemma":[0.9986418,0.0001304125,0.0003860749,0.0006281813,0.00005088794,0.0001625662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002357662,0.0001902405,0.01921692,0.00006503612,0.00009849911,0.00002342933,0.0001074401,0.00003378886,0.973653,0.0001491254,0.004030265,0.00007462847],"study_design_scores_gemma":[0.01052116,0.0006610776,0.2808168,0.0001906024,0.0002597295,0.00001632117,0.001590739,0.0002909017,0.5418881,0.0005188705,0.1603442,0.002901428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904425,0.003598351,0.00006725994,0.0002224631,0.0001368284,0.0006407535,0.004547055,0.00002266317,0.0003220864],"genre_scores_gemma":[0.9935196,0.0005111655,0.001942058,0.0002448363,0.00003549092,0.0000707911,0.003121005,0.00005492153,0.0005001275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4317648,"threshold_uncertainty_score":0.9998171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004415566563389049,"score_gpt":0.2072673813582045,"score_spread":0.2028518147948155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}