{"id":"W4308970537","doi":"10.3390/children9111734","title":"A Multicenter Study Evaluating the Discontinuation of Eculizumab Therapy in Children with Atypical Hemolytic Uremic Syndrome","year":2022,"lang":"en","type":"article","venue":"Children","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University; McMaster Children's Hospital","funders":"King Fahad Medical City","keywords":"Eculizumab; Discontinuation; Atypical hemolytic uremic syndrome; Medicine; Thrombotic microangiopathy; Internal medicine; Kidney disease; Pediatrics; Dialysis; Retrospective cohort study; Disease; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004699059,0.0001507057,0.0002531492,0.00009093313,0.0002221241,0.00001034826,0.000403556,0.00002637283,0.0006774222],"category_scores_gemma":[0.0000461306,0.00009937203,0.00005139095,0.0002584406,0.00008886532,0.00004697508,0.0002017057,0.0002423111,0.00001594886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007136523,"about_ca_system_score_gemma":0.00006896353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002843546,"about_ca_topic_score_gemma":0.00005570296,"domain_scores_codex":[0.9982051,0.0007906738,0.0003560056,0.0002966434,0.0001261366,0.0002253903],"domain_scores_gemma":[0.9992543,0.0001005636,0.0001915358,0.000407596,0.0000355459,0.0000104939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000632499,0.0009396518,0.9933559,0.000001506674,0.0004002552,0.00000130494,0.001639592,0.000190013,0.00141214,0.00001552632,0.0001178589,0.001293775],"study_design_scores_gemma":[0.006104781,0.002224659,0.9899815,0.00002381859,0.00006973145,0.0001251393,0.001096081,0.00002766667,0.0002106596,0.00001166002,0.000004704148,0.0001195695],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961276,0.0009062503,0.000004871731,0.00007975406,0.00007712725,0.002690006,0.00007232284,0.00002720618,0.00001488096],"genre_scores_gemma":[0.9992937,0.000002123962,0.000007020185,0.00004850372,0.00001049917,0.0003230901,0.0002418908,0.00001722536,0.00005595956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005472282,"threshold_uncertainty_score":0.7417297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060718182938391,"score_gpt":0.2873760908290317,"score_spread":0.2667689089996478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}