{"id":"W4308970959","doi":"10.3390/molecules27227779","title":"Platelet Desialylation Is a Novel Mechanism and Therapeutic Target in Daboia siamensis and Agkistrodon halys Envenomation-Induced Thrombocytopenia","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; University of Toronto; Science and Technology Planning Project of Guangdong Province; Guangdong Provincial Hospital of Traditional Chinese Medicine","keywords":"Envenomation; Venom; Coagulopathy; Antivenom; Platelet; Viperidae; Immunology; Biology; Consumptive Coagulopathy; Snake venom; Neuraminidase; Pharmacology; Ophidia; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006584555,0.000245764,0.000206055,0.0001121745,0.0001133066,0.0001730124,0.0001271651,0.0002317553,0.0004427407],"category_scores_gemma":[0.00005006402,0.00005138446,0.0001911455,0.00007704671,0.0001382006,0.00009904878,0.0001336708,0.0003576412,0.00006362082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598523,"about_ca_system_score_gemma":0.0001356998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580613,"about_ca_topic_score_gemma":0.000742837,"domain_scores_codex":[0.9999703,0.00000525627,0.000003442993,0.000005537683,0.00000728032,0.000008118143],"domain_scores_gemma":[0.9999839,0.000001583199,0.000006501711,0.000001265701,0.000002535467,0.000004225538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001166176,0.0001677492,0.004309705,0.0005732441,0.00007679326,0.001142944,0.00007422743,0.0001935855,0.9603711,0.000373975,0.0002971947,0.03125325],"study_design_scores_gemma":[0.0005611584,0.00841464,0.1273919,0.0001232106,0.0006358109,0.01540262,0.0003089477,0.005013968,0.8123477,0.0005727116,0.02919527,0.00003205779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763249,0.02003158,0.001599168,0.0002624713,0.00002963486,0.00005456967,0.00006266392,0.00003855472,0.001596308],"genre_scores_gemma":[0.9926332,0.00585175,0.0005425619,0.00009794175,0.00001669797,0.00002269607,0.00009089457,0.000001692109,0.0007426831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004580613,"threshold_uncertainty_score":0.001481116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792575730482943,"score_gpt":0.2377919040032539,"score_spread":0.2198661466984245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}