{"id":"W4308970959","doi":"10.3390/molecules27227779","title":"Platelet Desialylation Is a Novel Mechanism and Therapeutic Target in Daboia siamensis and Agkistrodon halys Envenomation-Induced Thrombocytopenia","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; University of Toronto; Science and Technology Planning Project of Guangdong Province; Guangdong Provincial Hospital of Traditional Chinese Medicine","keywords":"Envenomation; Venom; Coagulopathy; Antivenom; Platelet; Viperidae; Immunology; Biology; Consumptive Coagulopathy; Snake venom; Neuraminidase; Pharmacology; Ophidia; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502091,0.0001360827,0.0001715252,0.0000651716,0.0002180029,0.00003099833,0.00006976802,0.0000551113,0.00003400066],"category_scores_gemma":[0.0000153675,0.0001425958,0.00002869433,0.00008343186,0.00003158773,0.000004710826,0.0001533448,0.00007764874,0.000001409744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000254494,"about_ca_system_score_gemma":0.00002588935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006696389,"about_ca_topic_score_gemma":0.00004615649,"domain_scores_codex":[0.9991901,0.00005982606,0.0001777588,0.0003050224,0.0001169086,0.000150369],"domain_scores_gemma":[0.9997267,0.00000912663,0.00007664676,0.0001293765,0.00002313879,0.00003502531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005268265,0.00006361838,0.0007931267,0.00001248167,0.00005420605,0.000003957785,0.0008005911,0.00009840699,0.9939965,0.002866178,0.00004548073,0.001212772],"study_design_scores_gemma":[0.007090574,0.002759228,0.1517207,0.00003580398,0.0001307552,0.0002608156,0.004462789,0.0199654,0.7800546,0.01336662,0.01846008,0.001692592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961764,0.0008138271,0.001897752,0.0005194511,0.00003033138,0.0002034274,0.00003094861,0.0000106513,0.0003172343],"genre_scores_gemma":[0.9977921,0.00007638958,0.001198495,0.0006973397,0.00002066407,0.00004959187,0.00006022338,0.00001776739,0.00008745535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2139419,"threshold_uncertainty_score":0.5814888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792575730482943,"score_gpt":0.2377919040032539,"score_spread":0.2198661466984245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}