{"id":"W4308976535","doi":"10.1093/neuonc/noac209.183","title":"CSIG-34. LIN28B-LET-7-PBK PATHWAY IS AN IMPORTANT REGULATOR OF GROUP 3 MEDULLOBLASTOMA PROLIFERATION","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Gene knockdown; Cell growth; Apoptosis; Small hairpin RNA; Cancer research; Downregulation and upregulation; Medulloblastoma; Metastasis; Biology; Cell cycle; Stem cell; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006116001,0.0002915157,0.0002146578,0.0002676167,0.0002545536,0.0002618246,0.000169556,0.000263562,0.003940004],"category_scores_gemma":[0.00006403173,0.000132732,0.0002606582,0.0001491298,0.0001922414,0.0001360169,0.0002128352,0.0008964433,0.0009692942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004833049,"about_ca_system_score_gemma":0.0004237522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001554927,"about_ca_topic_score_gemma":0.002438701,"domain_scores_codex":[0.9999136,0.00000918123,0.000003587999,0.00001470973,0.00002997878,0.00002890674],"domain_scores_gemma":[0.9999462,0.000005143338,0.00001191844,0.000004134022,0.00000419416,0.00002841002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002516521,0.00005354259,0.000642026,0.00004742634,0.000007776094,0.0001053786,0.00000990258,0.0000779298,0.9957646,0.0001446211,0.0003842862,0.002510804],"study_design_scores_gemma":[0.00008490491,0.0006728068,0.04638555,0.00002283588,0.00003750482,0.0009471366,0.00008794075,0.001751955,0.9367373,0.0002227892,0.01304085,0.00000840945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985001,0.003108954,0.002280954,0.000456011,0.00006748005,0.00006531103,0.002174031,0.0003873769,0.006458881],"genre_scores_gemma":[0.9885217,0.001036911,0.001839642,0.0001553162,0.000009031497,0.00005832149,0.002416795,0.00004266883,0.005919602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003940004,"threshold_uncertainty_score":0.01318067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988029458835347,"score_gpt":0.2809091780106301,"score_spread":0.2610288834222767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}