{"id":"W4308976783","doi":"10.1093/neuonc/noac209.327","title":"CTNI-62. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Confidence interval; Clinical endpoint; Glioma; Oncology; Gastroenterology; Surgery; Clinical trial; Receptor; Neurotrophin; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018843,0.0003783319,0.0009817643,0.000243139,0.0002110035,0.0005807941,0.0002838352,0.0002986564,0.001880034],"category_scores_gemma":[0.0009862399,0.0001407926,0.0005592936,0.000466247,0.0002968835,0.000437827,0.0002147839,0.0007429364,0.0005811049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001035382,"about_ca_system_score_gemma":0.001092302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342207,"about_ca_topic_score_gemma":0.004864227,"domain_scores_codex":[0.9995565,0.0001395393,0.00004695794,0.0001009042,0.00009548808,0.00006061453],"domain_scores_gemma":[0.9994354,0.00008321179,0.000204004,0.00003396524,0.00006995598,0.0001735812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1675676,0.00441554,0.1958866,0.004346007,0.002999521,0.001248554,0.0002894624,0.006024868,0.07940513,0.000687324,0.0293974,0.507732],"study_design_scores_gemma":[0.098473,0.1416674,0.6435521,0.00102722,0.005358498,0.006653469,0.0002786086,0.0107887,0.02794334,0.000987667,0.06309963,0.0001703917],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637094,0.02372892,0.0004510007,0.0005825427,0.00009686129,0.0004463085,0.004299338,0.0001158325,0.00656998],"genre_scores_gemma":[0.9843892,0.004736098,0.0006105453,0.0006069468,0.00009165536,0.0003100924,0.007968185,0.0000185862,0.001268681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880034,"threshold_uncertainty_score":0.007512212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008525808754963329,"score_gpt":0.2388820065276836,"score_spread":0.2303561977727203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}