{"id":"W4308976790","doi":"10.1093/neuonc/noac209.276","title":"CTNI-10. RANDOMIZED PIVOTAL STUDY OF BLOOD-BRAIN BARRIER (BBB) DISRUPTION USING EXABLATE MODEL 4000 WITH STANDARD OF CARE (SOC) THERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) BRAIN METASTASES: LIMITLESS TRIAL","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Oncology; Lung cancer; Internal medicine; Randomized controlled trial; Clinical endpoint; non-small cell lung cancer (NSCLC); Pembrolizumab; Progression-free survival; Randomization; Immunotherapy; Cancer; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003451747,0.002489131,0.002402622,0.0005173896,0.0004592893,0.001625765,0.001499911,0.002806436,0.006377134],"category_scores_gemma":[0.002375433,0.0006901208,0.001985111,0.0004866547,0.001437201,0.001495735,0.0005415544,0.003927805,0.001370871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001311844,"about_ca_system_score_gemma":0.001678535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182766,"about_ca_topic_score_gemma":0.002668589,"domain_scores_codex":[0.9990242,0.0005944642,0.00004755904,0.0001521631,0.0000750542,0.0001066214],"domain_scores_gemma":[0.9985619,0.0003269646,0.0004067192,0.0001167921,0.0001271247,0.0004604772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9764642,0.004962714,0.0004158321,0.000918117,0.0007480244,0.00004547467,0.0000339643,0.0005396027,0.004572791,0.0003234121,0.002233797,0.008742073],"study_design_scores_gemma":[0.9192297,0.07697324,0.0007491923,0.00005269135,0.000422944,0.00004480129,0.00001438096,0.0005614285,0.0006251169,0.0001950505,0.001112239,0.00001914724],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554813,0.01108713,0.001692693,0.002514822,0.001705298,0.012865,0.005139243,0.0004804461,0.009033982],"genre_scores_gemma":[0.9451082,0.005913196,0.005604682,0.004484077,0.001346722,0.01617139,0.007025068,0.0001210954,0.01422572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006377134,"threshold_uncertainty_score":0.02133363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02676823639182252,"score_gpt":0.3253090690855392,"score_spread":0.2985408326937167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}