{"id":"W4308976883","doi":"10.1093/neuonc/noac209.135","title":"STEM-18. EPIGENETIC AND MOLECULAR COORDINATION BETWEEN HDAC2 AND SMAD3-SKI IS REQUIRED FOR GROWTH AND STEM CELL CHARACTERISTICS OF BRAIN TUMOUR STEM CELLS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Neurosciences, Mental Health and Addiction; Government of Canada; University of Calgary","funders":"","keywords":"Epigenetics; Biology; Stem cell; Chromatin; Cancer stem cell; Neural stem cell; Cancer research; Cell growth; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011452,0.0003117812,0.0002603713,0.0001974814,0.0001878893,0.0003475045,0.000209559,0.0002079317,0.002880358],"category_scores_gemma":[0.00006936702,0.0001862682,0.0003685598,0.0001310169,0.000218439,0.0001438312,0.0002427477,0.0003727532,0.0009653961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003528252,"about_ca_system_score_gemma":0.0003468386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008405517,"about_ca_topic_score_gemma":0.002006189,"domain_scores_codex":[0.9998628,0.00001029965,0.00001496714,0.00003629747,0.00004949339,0.00002609636],"domain_scores_gemma":[0.9998925,0.000005869434,0.00004066788,0.000009691412,0.00001219268,0.00003918604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005670516,0.00001029817,0.0004379473,0.00003717808,0.000005821485,0.00005811741,0.00001002954,0.00003494487,0.9981458,0.0001281302,0.00007229622,0.001002712],"study_design_scores_gemma":[0.00001544185,0.0001003244,0.01134043,0.000006736178,0.00002031104,0.0003435916,0.0000293579,0.0009235709,0.9805726,0.00005061659,0.006593182,0.000003828288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789966,0.002632449,0.009878235,0.0002555191,0.0001223688,0.00005788415,0.002830231,0.0004775643,0.004749139],"genre_scores_gemma":[0.9892998,0.0005522808,0.001855819,0.00008534381,0.00001365909,0.00003884393,0.002554201,0.00005385689,0.005546188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002880358,"threshold_uncertainty_score":0.009635806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961462110635535,"score_gpt":0.2774568564191405,"score_spread":0.2578422353127852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}