{"id":"W4308976884","doi":"10.1093/neuonc/noac209.400","title":"DDDR-35. TARGETING GBM INVASION BY INHIBITING KCNA1 WITH 4-AMINOPYRIDINE: AN FDA APPROVED DRUG THAT EASILY PASS THROUGH THE BBB","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; Associazione Italiana per la Ricerca sul Cancro; Hospital for Sick Children; Lazio Innova","keywords":"Medicine; Drug; Glioblastoma; Cancer research; 4-Aminopyridine; Oncology; Pharmacology; Pathology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009568926,0.0003485473,0.0002484387,0.0003158344,0.0001223102,0.0001888358,0.0001545945,0.0002327716,0.001684578],"category_scores_gemma":[0.00005740785,0.0001153906,0.0002237788,0.0001876936,0.00016202,0.0001540209,0.00009905719,0.000489563,0.0003983317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086445,"about_ca_system_score_gemma":0.0002840718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151807,"about_ca_topic_score_gemma":0.002195094,"domain_scores_codex":[0.9999131,0.00001167614,0.000007306117,0.00002013559,0.00002159156,0.00002622882],"domain_scores_gemma":[0.9999654,0.000005214573,0.000009745786,0.000004017254,0.000005458685,0.00001006607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003339757,0.0001240929,0.0001878718,0.00008107554,0.00000906637,0.00003297991,0.00001378909,0.0001596856,0.9937459,0.0001334482,0.0003194872,0.004858558],"study_design_scores_gemma":[0.0000817083,0.002188681,0.003290002,0.000009719405,0.00003146031,0.0002430093,0.0000192903,0.0008913475,0.9873337,0.00004252823,0.00586066,0.000008003172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870568,0.004972568,0.002649383,0.0002562204,0.0001056865,0.00007511666,0.001397192,0.0002705945,0.003216553],"genre_scores_gemma":[0.9875425,0.002612858,0.00387556,0.0001118802,0.00001227088,0.00006141019,0.001723191,0.00001914529,0.004041241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684578,"threshold_uncertainty_score":0.00563544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642005300517969,"score_gpt":0.2749201693302587,"score_spread":0.248500116325079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}