{"id":"W4308977070","doi":"10.1093/neuonc/noac209.333","title":"CTNI-68. FIREFLY-1 (PNOC026): PHASE 2 STUDY OF PAN-RAF INHIBITOR TOVORAFENIB IN PEDIATRIC AND YOUNG ADULT PATIENTS WITH RAF-ALTERED RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA OR ADVANCED SOLID TUMORS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; McGill University Health Centre; Université de Montréal; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Gastroenterology; Response Evaluation Criteria in Solid Tumors; Phases of clinical research; Vomiting; Anemia; Oncology; Glioma; Surgery; Clinical trial; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001428003,0.0004242233,0.001083512,0.0005499937,0.000174785,0.00001588284,0.000212138,0.00009255316,0.0001131018],"category_scores_gemma":[0.0004116313,0.0002903629,0.00007751443,0.001061957,0.0001006302,0.0001157422,0.0003545093,0.0004709243,0.000003371162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000393041,"about_ca_system_score_gemma":0.0004069887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006185366,"about_ca_topic_score_gemma":0.0002688889,"domain_scores_codex":[0.9966317,0.0004397243,0.0008883381,0.0008423587,0.0006350995,0.0005627519],"domain_scores_gemma":[0.9979472,0.0003780212,0.0006743573,0.0005131291,0.0002301981,0.0002571175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04987404,0.09480272,0.7607716,0.0004236755,0.0002598342,0.01726479,0.009069039,0.00005176641,0.008794206,0.000003463544,0.001497051,0.05718784],"study_design_scores_gemma":[0.2819814,0.2932491,0.3937445,0.0002998814,0.001460306,0.001055142,0.007491461,0.0002790656,0.01795421,0.00001257291,0.001526255,0.0009461298],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936951,0.000352039,2.530644e-7,0.0004264119,0.000749736,0.004587295,0.0001108534,0.00005777347,0.00002056796],"genre_scores_gemma":[0.9971285,0.00009787548,0.0001308915,0.0001890369,0.0001760926,0.002111624,0.00009247979,0.00006543673,0.000008080897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3670271,"threshold_uncertainty_score":0.9999549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680412607724228,"score_gpt":0.3232962237666636,"score_spread":0.3064920976894213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}