{"id":"W4308977070","doi":"10.1093/neuonc/noac209.333","title":"CTNI-68. FIREFLY-1 (PNOC026): PHASE 2 STUDY OF PAN-RAF INHIBITOR TOVORAFENIB IN PEDIATRIC AND YOUNG ADULT PATIENTS WITH RAF-ALTERED RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA OR ADVANCED SOLID TUMORS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; McGill University Health Centre; Université de Montréal; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Gastroenterology; Response Evaluation Criteria in Solid Tumors; Phases of clinical research; Vomiting; Anemia; Oncology; Glioma; Surgery; Clinical trial; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006913066,0.0009743441,0.001073412,0.0002924237,0.0002091535,0.0005969828,0.0005160853,0.0004926376,0.002258604],"category_scores_gemma":[0.0003386348,0.0003473015,0.0007531303,0.0002552864,0.0003522307,0.0003599205,0.0002414426,0.001713263,0.0004726654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007762596,"about_ca_system_score_gemma":0.001417195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591313,"about_ca_topic_score_gemma":0.006098573,"domain_scores_codex":[0.9998465,0.00005408302,0.000007562087,0.00002783774,0.00001751804,0.00004662319],"domain_scores_gemma":[0.9997762,0.00001984953,0.00003806849,0.000008916354,0.00001676426,0.0001401867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4500164,0.07930185,0.01800071,0.002670595,0.002153906,0.001499971,0.0006268189,0.004767307,0.1608418,0.0008970237,0.01717973,0.262044],"study_design_scores_gemma":[0.4324248,0.5047088,0.02881368,0.000133408,0.0009780112,0.001826794,0.0001328108,0.002718831,0.01500448,0.000284245,0.0129074,0.0000668494],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898094,0.004420706,0.0005705124,0.0003992265,0.00009948609,0.001425147,0.001292677,0.0001466525,0.001836263],"genre_scores_gemma":[0.9836029,0.005247765,0.001866493,0.0006594669,0.0001129217,0.001626285,0.003233494,0.00003012082,0.003620564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002258604,"threshold_uncertainty_score":0.007555783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680412607724228,"score_gpt":0.3232962237666636,"score_spread":0.3064920976894213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}