{"id":"W4308977228","doi":"10.1093/neuonc/noac209.462","title":"EPCO-28. DOT1L AND PRC2 REGULATE A SHARED EPIGENETIC MECHANISM IN GLIOBLASTOMA AND MIXED LINEAGE LEUKEMIA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Neurosciences, Mental Health and Addiction; Government of Canada; University of Calgary","funders":"","keywords":"Epigenetics; PRC2; Biology; DNA methylation; Chromatin; Cancer research; Histone; Genetics; EZH2; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037689,0.0002103896,0.0002460202,0.0002528105,0.0001011856,0.0002859857,0.000155424,0.000153851,0.00124846],"category_scores_gemma":[0.00008816442,0.0001124167,0.0001388873,0.0001471423,0.0001752003,0.0001026509,0.000253502,0.0002357435,0.0003219589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201417,"about_ca_system_score_gemma":0.0001951856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008756867,"about_ca_topic_score_gemma":0.001671256,"domain_scores_codex":[0.9998864,0.00001127459,0.00001037963,0.00002224576,0.00004260159,0.00002717129],"domain_scores_gemma":[0.9999297,0.000006457061,0.00002581901,0.000005822274,0.00000921183,0.00002298901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001757263,0.00001742435,0.0008555875,0.00002179909,0.000005482814,0.00004799276,0.000005830105,0.00007334462,0.99675,0.00008825292,0.00003606231,0.001922499],"study_design_scores_gemma":[0.00004174336,0.0005357076,0.05985564,0.000006907727,0.00002768416,0.0005988497,0.0000499494,0.001492519,0.9338393,0.00008974521,0.003456198,0.000005771479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941758,0.002212176,0.001438436,0.00008852809,0.000008585721,0.00002284779,0.0005315892,0.00005815601,0.001463867],"genre_scores_gemma":[0.995505,0.0004946911,0.0006707234,0.00005523235,0.000002296341,0.00002044997,0.0008594458,0.000008701861,0.002383464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124846,"threshold_uncertainty_score":0.004176497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082383980858814,"score_gpt":0.2540997245746737,"score_spread":0.2432758847660856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}