{"id":"W4308977249","doi":"10.1093/neuonc/noac209.594","title":"PATH-21. INVESTIGATING CHANGES IN IDH MUTATION STATUS AT GLIOMA RECURRENCE","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"IDH2; Isocitrate dehydrogenase; IDH1; Glioma; Sanger sequencing; Immunohistochemistry; Carcinogenesis; Biology; Pathology; Mutation; Methylation; Biopsy; Cancer research; PTEN; Oncology; Medicine; Cancer; Gene; Genetics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000345554,0.0002110961,0.0002603291,0.001048578,0.0002544411,0.0004772043,0.0003258661,0.0002999856,0.003264508],"category_scores_gemma":[0.0009373736,0.0001016528,0.0001503671,0.0005914191,0.000245918,0.0002740397,0.0002985772,0.0002159486,0.0008915068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000505765,"about_ca_system_score_gemma":0.0003074058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002065202,"about_ca_topic_score_gemma":0.002064266,"domain_scores_codex":[0.9998301,0.00002625089,0.00002186168,0.00003994046,0.00004394076,0.00003780513],"domain_scores_gemma":[0.9996064,0.00007805839,0.0001357003,0.00002801609,0.00008035832,0.00007153463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008431491,0.00005057906,0.9251925,0.0001024455,0.00003505517,0.004229966,0.0002503777,0.0002952816,0.03377893,0.0001683135,0.0007034953,0.03434977],"study_design_scores_gemma":[0.00002230657,0.0007092031,0.9332713,0.00001898578,0.00008238902,0.02037808,0.0003792932,0.001691086,0.03843277,0.0002656396,0.004734222,0.00001473122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954417,0.0005024302,0.0006886196,0.00008911717,0.00001192578,0.0000393243,0.0006617465,0.00006232017,0.002502735],"genre_scores_gemma":[0.997173,0.0001553768,0.001058952,0.00003660925,0.000006940483,0.00002694926,0.0006317002,0.00001497967,0.0008956267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003264508,"threshold_uncertainty_score":0.01092088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03756683201148126,"score_gpt":0.3134869378130963,"score_spread":0.2759201058016151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}