{"id":"W4308977251","doi":"10.1093/neuonc/noac209.271","title":"CTNI-04. TRAM-01: A PHASE 2 STUDY OF TRAMETINIB FOR PEDIATRIC PATIENTS WITH NEUROFIBROMATOSIS TYPE 1 AND PLEXIFORM NEUROFIBROMAS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; McGill University Health Centre; Centre Hospitalier Universitaire de Sherbrooke; Hospital for Sick Children; Centre hospitalier universitaire de Québec; BC Children's Hospital; SickKids Foundation; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Trametinib; Neurofibromatosis; Adverse effect; Dysgeusia; Internal medicine; Surgery; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001303714,0.001175599,0.001363709,0.0003349859,0.000316477,0.0008386209,0.0008309539,0.0008603578,0.002709481],"category_scores_gemma":[0.0005332428,0.0004078627,0.0008353008,0.0003683129,0.0005521802,0.0005913686,0.0003036567,0.002764339,0.0005929382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000867173,"about_ca_system_score_gemma":0.00195468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222397,"about_ca_topic_score_gemma":0.003832027,"domain_scores_codex":[0.9997681,0.00009140022,0.00001315702,0.00004039362,0.00002827539,0.00005875415],"domain_scores_gemma":[0.9995358,0.00004180464,0.0000761175,0.00002248546,0.00003099466,0.0002927917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4428452,0.1212538,0.02061376,0.001994168,0.002138847,0.001586339,0.0005557166,0.005459278,0.08091442,0.0008695772,0.01580977,0.3059592],"study_design_scores_gemma":[0.475486,0.4669081,0.03133887,0.00009651918,0.000811855,0.002364802,0.000112598,0.00327196,0.01023045,0.000254725,0.009062666,0.00006154177],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884678,0.004931789,0.0006231114,0.0006023107,0.0001203618,0.002020325,0.001343109,0.0001377983,0.001753546],"genre_scores_gemma":[0.9816294,0.004303188,0.003104278,0.001117079,0.0001806712,0.00291155,0.003299406,0.000038375,0.0034161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002709481,"threshold_uncertainty_score":0.009064078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775016837810763,"score_gpt":0.3290209320926506,"score_spread":0.301270763714543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}