{"id":"W4308977430","doi":"10.1093/neuonc/noac209.177","title":"CSIG-28. THE HEDGEHOG GENE EXPRESSION PROGRAM REGULATES LIPID FEEDBACK MECHANISMS UNDERLYING HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Smoothened; Hedgehog signaling pathway; Hedgehog; GLI1; Biology; Cilium; Sonic hedgehog; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0008929953,0.0004669584,0.0005325526,0.000108134,0.001358251,0.00005800577,0.0009028271,0.0003564782,0.0001216437],"category_scores_gemma":[0.0005580919,0.0003939161,0.0002827301,0.0004205056,0.0003016914,0.000008809037,0.001485154,0.0006659325,0.0000261026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242665,"about_ca_system_score_gemma":0.0003681266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001626902,"about_ca_topic_score_gemma":0.00005195474,"domain_scores_codex":[0.9957297,0.001283483,0.0005887285,0.001018597,0.0004881018,0.0008913362],"domain_scores_gemma":[0.9981304,0.0002858064,0.0004120301,0.0008093453,0.0001801001,0.0001822597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002353957,0.000467504,0.0001315112,0.00001512934,0.0001395002,0.00006186144,0.0005101752,0.0008561079,0.9779343,0.00007471427,0.01057916,0.008994666],"study_design_scores_gemma":[0.001551604,0.004513378,0.0004683865,0.00001561372,0.00008791185,0.0001946159,0.001274782,0.0003472477,0.7425601,0.0003740079,0.2481215,0.0004908478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898468,0.001042396,0.0008900821,0.002734458,0.00222933,0.001454514,0.0000697858,0.0002945019,0.001438188],"genre_scores_gemma":[0.9938931,0.0001431293,0.001515914,0.002440728,0.0003429484,0.0009113171,0.0002098441,0.0001229502,0.0004200349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2375424,"threshold_uncertainty_score":0.9999418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03010825019204413,"score_gpt":0.2916004519560762,"score_spread":0.2614922017640321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}