{"id":"W4308977430","doi":"10.1093/neuonc/noac209.177","title":"CSIG-28. THE HEDGEHOG GENE EXPRESSION PROGRAM REGULATES LIPID FEEDBACK MECHANISMS UNDERLYING HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Smoothened; Hedgehog signaling pathway; Hedgehog; GLI1; Biology; Cilium; Sonic hedgehog; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007149793,0.0002530552,0.0002164516,0.0002600218,0.0002313419,0.0002414093,0.0001887865,0.0002027475,0.002088179],"category_scores_gemma":[0.0000692248,0.0001437877,0.0002305454,0.0001472806,0.0002710313,0.00009898344,0.0002638522,0.0004244925,0.001006429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006621851,"about_ca_system_score_gemma":0.0004120627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002821276,"about_ca_topic_score_gemma":0.005644003,"domain_scores_codex":[0.9998814,0.0000094922,0.000006567002,0.00002992566,0.00003918852,0.00003345859],"domain_scores_gemma":[0.9999226,0.000004969516,0.0000188531,0.000006259584,0.000009276898,0.00003803942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006530743,0.000008716914,0.0002235352,0.00001855711,0.000001866359,0.0000423571,0.000007489259,0.00004256759,0.9988214,0.0000878072,0.00007586726,0.0006045947],"study_design_scores_gemma":[0.0000285755,0.0001596378,0.02776314,0.00001484985,0.00001704597,0.000213495,0.0001038567,0.001913391,0.9633177,0.0001457606,0.006313597,0.000008956164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873086,0.001113888,0.002652413,0.000209752,0.00004899029,0.00006072615,0.003029382,0.0002444992,0.005331818],"genre_scores_gemma":[0.9897445,0.0003704711,0.001627468,0.0001119683,0.000004357421,0.00003963879,0.00206392,0.00006018189,0.005977512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002821276,"threshold_uncertainty_score":0.006985664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03010825019204413,"score_gpt":0.2916004519560762,"score_spread":0.2614922017640321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}