{"id":"W4308977734","doi":"10.1093/neuonc/noac209.296","title":"CTNI-31. COG ACNS1721: PHASE 2 STUDY OF VELIPARIB AND LOCAL IRRADIATION, FOLLOWED BY MAINTENANCE VELIPARIB AND TEMOZOLOMIDE, IN PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA WITHOUT H3 K27M OR BRAF MUTATIONS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Veliparib; Temozolomide; Medicine; Internal medicine; PARP inhibitor; Oncology; Radiation therapy; Glioma; Interim analysis; Clinical trial; Cancer research; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561465,0.001936016,0.002025557,0.0006791331,0.0005447961,0.00098862,0.001254687,0.0009676974,0.004453212],"category_scores_gemma":[0.00068786,0.0007930623,0.001355912,0.0006794627,0.001326915,0.000757847,0.0004689765,0.002791022,0.0009561272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001702724,"about_ca_system_score_gemma":0.0035754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002205547,"about_ca_topic_score_gemma":0.006856634,"domain_scores_codex":[0.9995112,0.0002205015,0.00002525483,0.0001000001,0.00004209268,0.0001009808],"domain_scores_gemma":[0.9992879,0.00006333652,0.0001040498,0.00005547423,0.00004238815,0.0004469289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8658379,0.060588,0.004351587,0.0006981058,0.0007662653,0.0001818003,0.0001916988,0.002138057,0.01923147,0.000283396,0.001823421,0.04390828],"study_design_scores_gemma":[0.6093206,0.3783767,0.006999692,0.00003264295,0.0003694998,0.0002203031,0.00004458674,0.0006678656,0.002095188,0.0001624921,0.001683543,0.00002697111],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910526,0.001366419,0.0002872955,0.0002465599,0.0001007913,0.004284404,0.001150788,0.00006988802,0.00144136],"genre_scores_gemma":[0.9828352,0.001844017,0.002243175,0.0005526194,0.0001438774,0.00620123,0.002983637,0.00003188042,0.003164293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004453212,"threshold_uncertainty_score":0.01489747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289871377875871,"score_gpt":0.2864777575381292,"score_spread":0.2735790437593705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}