{"id":"W4308977734","doi":"10.1093/neuonc/noac209.296","title":"CTNI-31. COG ACNS1721: PHASE 2 STUDY OF VELIPARIB AND LOCAL IRRADIATION, FOLLOWED BY MAINTENANCE VELIPARIB AND TEMOZOLOMIDE, IN PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA WITHOUT H3 K27M OR BRAF MUTATIONS","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Veliparib; Temozolomide; Medicine; Internal medicine; PARP inhibitor; Oncology; Radiation therapy; Glioma; Interim analysis; Clinical trial; Cancer research; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000191997,0.0003133818,0.0008470365,0.0003370236,0.0002217596,0.0000192024,0.000120268,0.0001056881,0.00005756033],"category_scores_gemma":[0.0002995375,0.0002488294,0.0000372246,0.0007679536,0.0002316207,0.0001119011,0.0001374999,0.0003270036,0.000002126048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002965507,"about_ca_system_score_gemma":0.0003223894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006237644,"about_ca_topic_score_gemma":0.0009722489,"domain_scores_codex":[0.9975327,0.0003389551,0.0006271618,0.0006718349,0.0004187861,0.0004105163],"domain_scores_gemma":[0.9981481,0.0007622136,0.0003576205,0.000334471,0.0001554866,0.0002421359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007099434,0.02769449,0.9278794,0.00005244734,0.0003790089,0.002123498,0.003291016,0.0003415592,0.008147517,0.00005413319,0.009985754,0.01295173],"study_design_scores_gemma":[0.1860263,0.04999367,0.748966,0.00004812042,0.0009385681,0.0002022376,0.004028924,0.0008290961,0.001371807,0.00002786483,0.007162862,0.0004044947],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995131,0.0002019934,0.00002401031,0.001580022,0.0002170746,0.002575754,0.0001959493,0.00004118523,0.00003301461],"genre_scores_gemma":[0.9977482,0.00003919926,0.000201712,0.0007287914,0.00002581619,0.0009494398,0.0002446747,0.00004726547,0.00001493098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1789269,"threshold_uncertainty_score":0.9999964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289871377875871,"score_gpt":0.2864777575381292,"score_spread":0.2735790437593705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}