{"id":"W4308977735","doi":"10.1093/neuonc/noac209.019","title":"BIOM-09. GUIDING PRECISION THERAPEUTICS THROUGH INTERROGATING ONCOGENIC PATHWAY ACTIVATION","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Cancer research; Protein kinase B; Medicine; Signal transduction; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001281031,0.0007388467,0.0005350393,0.0007446156,0.0002018132,0.0008952278,0.0005178117,0.0006880613,0.005632035],"category_scores_gemma":[0.0007707021,0.0003906295,0.0003644676,0.0004925233,0.0004133299,0.0003684243,0.0007547458,0.0005915708,0.003649027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006843517,"about_ca_system_score_gemma":0.0007782633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006576863,"about_ca_topic_score_gemma":0.001271572,"domain_scores_codex":[0.9994509,0.0001167564,0.00003009131,0.000123502,0.0002254463,0.00005326562],"domain_scores_gemma":[0.9996153,0.0001003842,0.0001088662,0.00005630331,0.00007355097,0.00004551474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001710019,0.0003229381,0.01382352,0.0008232017,0.0001317451,0.000190428,0.00008855705,0.0130821,0.8167859,0.00426256,0.01759138,0.1311877],"study_design_scores_gemma":[0.0001671852,0.001230889,0.01427144,0.0000828893,0.0001064977,0.0007724265,0.00007381142,0.05875742,0.8553462,0.003881094,0.06523879,0.00007130059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6125916,0.01515121,0.2266713,0.004904945,0.00103337,0.0008835092,0.04335454,0.02351867,0.07189074],"genre_scores_gemma":[0.7745122,0.00379795,0.1807902,0.001397721,0.0001328738,0.0007165337,0.01997149,0.001071036,0.01761008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005632035,"threshold_uncertainty_score":0.01884109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08886516930571865,"score_gpt":0.3503146379101298,"score_spread":0.2614494686044112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}