{"id":"W4308977924","doi":"10.1093/neuonc/noac209.120","title":"STEM-03. MOLECULAR PROFILING OF PRIMARY VERSUS RECURRENT GLIOBLASTOMA BRAIN TUMOR STEM CELLS UNCOVERS SIGNALING MECHANISMS THAT PROMOTE THE AGGRESSIVENESS OF RECURRENT GLIOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Neurosciences, Mental Health and Addiction; Government of Canada; University of Calgary","funders":"","keywords":"Stem cell; Temozolomide; Cancer research; Brain tumor; Population; Cancer stem cell; Primary tumor; Medicine; Biology; Oncology; Cancer; Pathology; Internal medicine; Glioblastoma; Metastasis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945577,0.0002506168,0.0004258266,0.001031732,0.0003174843,0.0006607591,0.0002031169,0.0002964985,0.00326295],"category_scores_gemma":[0.0002174577,0.0001690975,0.0003240553,0.0009478719,0.0002155421,0.0001734389,0.0002261659,0.0003863637,0.0008053738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383057,"about_ca_system_score_gemma":0.0003737329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007579,"about_ca_topic_score_gemma":0.002148345,"domain_scores_codex":[0.9997802,0.000009918421,0.00001791905,0.00005761405,0.00008935174,0.00004498495],"domain_scores_gemma":[0.9998516,0.00002092742,0.00004455942,0.00001006122,0.00003424148,0.00003861003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000604559,0.00007754607,0.01429204,0.0002228641,0.00004221011,0.000188864,0.0001278573,0.0002676433,0.9661642,0.0002412145,0.001007991,0.01676304],"study_design_scores_gemma":[0.00005284086,0.001178914,0.2391086,0.00004559183,0.0001885283,0.001093296,0.0003495724,0.004095186,0.7342991,0.0004121844,0.01915122,0.00002489332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722837,0.00179893,0.003625992,0.0001789166,0.00004874037,0.0001455151,0.01846965,0.0005603462,0.002888281],"genre_scores_gemma":[0.9347682,0.001881778,0.008510422,0.0003127152,0.00003141073,0.0004070697,0.0465431,0.0001165876,0.00742864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00326295,"threshold_uncertainty_score":0.01091564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02463835456390587,"score_gpt":0.2747157493756938,"score_spread":0.2500773948117879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}