{"id":"W4308977979","doi":"10.1093/neuonc/noac209.1140","title":"MODL-12. A NOVEL GENETICALLY ENGINEERED H3.3G34R MODEL REVEALS COOPERATION WITH ATRX LOSS IN UPREGULATION OF HOXA CLUSTER GENES AND PROMOTION OF NEURONAL LINEAGE","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Context (archaeology); Biology; Gene; Cancer research; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003428006,0.0005755342,0.0004042007,0.0008255639,0.0003002672,0.0004206626,0.000629827,0.0007576091,0.002705062],"category_scores_gemma":[0.00009734544,0.0002970726,0.0003956048,0.0002994339,0.0004791864,0.0002794826,0.0003324394,0.001451396,0.001034262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006540917,"about_ca_system_score_gemma":0.0004162674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008625141,"about_ca_topic_score_gemma":0.001469253,"domain_scores_codex":[0.999655,0.00004211733,0.00003782733,0.00008554114,0.0000955456,0.00008401969],"domain_scores_gemma":[0.9996843,0.00002513703,0.0001314815,0.00002702608,0.0000155765,0.0001164636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003024992,0.0001303686,0.0001735615,0.00002626969,0.000006255818,0.0001184378,0.00001978847,0.00009907634,0.9978032,0.0003663179,0.0001293137,0.0008249345],"study_design_scores_gemma":[0.0001360779,0.001125377,0.002285213,0.00001259424,0.00002423476,0.0006296882,0.00005451298,0.001894158,0.986176,0.0001073004,0.007545467,0.000009403655],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839244,0.0007643886,0.008310884,0.000479268,0.0001512962,0.0001950243,0.002912952,0.0006241684,0.002637557],"genre_scores_gemma":[0.9758614,0.0005429013,0.009195799,0.0001601972,0.00002845258,0.0003164946,0.002317071,0.0002086096,0.01136899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002705062,"threshold_uncertainty_score":0.009049356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237888244673174,"score_gpt":0.2693146814726152,"score_spread":0.2455258570052978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}