{"id":"W4308992051","doi":"10.1172/jci159348","title":"Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; McGill University Health Centre","funders":"Medical Research Council; NIH Clinical Center; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Hackensack Meridian Health; NHLBI Division of Intramural Research; National Institute on Deafness and Other Communication Disorders; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Phaeohyphomycosis; Immunology; Macrophage; Biology; Immunologic Deficiency Syndromes; Medicine; Immune system; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266358,0.0003894899,0.0003033992,0.0001631181,0.0001587149,0.0002210218,0.0001069303,0.0002464745,0.001434181],"category_scores_gemma":[0.0002175457,0.00009843666,0.0001550304,0.00009143879,0.0001827748,0.00009324804,0.0001603449,0.0003252042,0.0002347747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001665549,"about_ca_system_score_gemma":0.0001209595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004066574,"about_ca_topic_score_gemma":0.0003778783,"domain_scores_codex":[0.9998817,0.00002425376,0.00001823283,0.00002707269,0.00001813625,0.00003056594],"domain_scores_gemma":[0.999903,0.00002673072,0.00001644907,0.00001010654,0.000007873152,0.00003588551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009747203,0.0002888782,0.01047027,0.00006508911,0.00003299503,0.002835627,0.00009289788,0.0001861175,0.9796228,0.000127673,0.0001334485,0.005169416],"study_design_scores_gemma":[0.0004955957,0.007602008,0.1816633,0.00005667294,0.000209815,0.04584346,0.0003237028,0.003694396,0.7544752,0.0002037759,0.005403362,0.00002874272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994307,0.000173743,0.0001372141,0.00001331066,0.000003449941,0.000007082331,0.00005159235,0.000006726052,0.0001761471],"genre_scores_gemma":[0.9993302,0.0001093403,0.0001618563,0.00001869459,0.000002269534,0.000006658137,0.0001062398,0.000002260306,0.0002625444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001434181,"threshold_uncertainty_score":0.004797816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07757930275382934,"score_gpt":0.3798325641240747,"score_spread":0.3022532613702453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}