{"id":"W4308998148","doi":"10.1016/j.scr.2022.102970","title":"Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D6*10/CYP3A5*3C and CYP2D6*10/CYP2C19*2","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Korea Evaluation Institute of Industrial Technology; Ministry of Science and ICT, South Korea; Ministry of Science ICT and Future Planning; National Research Foundation of Korea","keywords":"Biology; CYP2D6; Induced pluripotent stem cell; Cytochrome P450; Single-nucleotide polymorphism; CYP2C19; CYP3A4; Drug metabolism; Gene; Cell culture; CYP3A5; Genotype; Drug; Genetics; Enzyme; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009627384,0.0003547362,0.0004747178,0.0006565906,0.000270391,0.0005449672,0.0004683368,0.0005839744,0.003595722],"category_scores_gemma":[0.0008306412,0.0002646443,0.0005779039,0.0005994122,0.0002828163,0.0002273492,0.000405736,0.001028842,0.001181232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947736,"about_ca_system_score_gemma":0.0003477701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006430424,"about_ca_topic_score_gemma":0.001044799,"domain_scores_codex":[0.9992829,0.0001035368,0.0001599416,0.0001131749,0.0002901927,0.00005022007],"domain_scores_gemma":[0.9991035,0.0002122667,0.000155763,0.0002139201,0.0002109067,0.0001035242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004003075,0.0004579328,0.005241951,0.0002646582,0.0001424084,0.0009815033,0.0002098939,0.001744397,0.95127,0.003681852,0.003926762,0.03167829],"study_design_scores_gemma":[0.0003069718,0.001456793,0.01234181,0.00007098726,0.0003401632,0.002759798,0.0001660961,0.00955974,0.9169167,0.0008787708,0.05513901,0.00006318219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7316402,0.003473163,0.2132895,0.001339531,0.0009345334,0.004609239,0.02682408,0.001540725,0.01634892],"genre_scores_gemma":[0.8332516,0.002675344,0.109368,0.00139555,0.0001576541,0.00253743,0.03324528,0.0002401333,0.01712896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003595722,"threshold_uncertainty_score":0.01202887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3674746136622723,"score_gpt":0.4653036000068799,"score_spread":0.09782898634460763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}