{"id":"W4309004306","doi":"10.3390/molecules27227794","title":"Discovery of Levesquamide B through Global Natural Product Social Molecular Networking","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Atlantic Canada Opportunities Agency; Innovation PEI","keywords":"Natural product; Natural (archaeology); Product (mathematics); Streptomyces; Computational biology; Chemistry; Stereochemistry; Computer science; Biology; Genetics; Bacteria; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146488,0.0001645325,0.0003122444,0.00003114496,0.0002048296,0.00002184902,0.0001647152,0.00003372976,0.00004736021],"category_scores_gemma":[0.00006187295,0.0001378948,0.0001895138,0.0004166234,0.0001130906,0.00008703174,0.0002401268,0.0002588993,0.000002309434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263378,"about_ca_system_score_gemma":0.00007821345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001041467,"about_ca_topic_score_gemma":0.000004880902,"domain_scores_codex":[0.998627,0.00009629699,0.0002548016,0.0003675227,0.0003722927,0.000282064],"domain_scores_gemma":[0.9995463,0.00001272893,0.0001257189,0.0002305836,0.00006194726,0.00002274462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003973605,0.000180372,0.000413414,0.0001063685,0.000143468,0.0001335197,0.0001867142,0.0000549556,0.9783986,0.003649316,0.006037963,0.01029795],"study_design_scores_gemma":[0.001232607,0.0003354137,0.007437791,0.00007047896,0.0003348599,0.0002223503,0.0003689954,0.0001346955,0.9544921,0.001760032,0.03307024,0.0005404225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865689,0.005170847,0.0001456282,0.005355554,0.0006189321,0.000346691,0.00006597173,0.0000499356,0.001677557],"genre_scores_gemma":[0.9971842,0.00001437262,0.0009238786,0.001062002,0.0004125477,0.000002932336,0.00005908762,0.00001919568,0.0003218236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02703228,"threshold_uncertainty_score":0.5623186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456791141241376,"score_gpt":0.2596309104000521,"score_spread":0.2450629989876383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}