{"id":"W4309004306","doi":"10.3390/molecules27227794","title":"Discovery of Levesquamide B through Global Natural Product Social Molecular Networking","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Atlantic Canada Opportunities Agency; Innovation PEI","keywords":"Natural product; Natural (archaeology); Product (mathematics); Streptomyces; Computational biology; Chemistry; Stereochemistry; Computer science; Biology; Genetics; Bacteria; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009351099,0.0002646001,0.000144841,0.0003240368,0.0001463033,0.000256693,0.0001571182,0.0001976194,0.001978004],"category_scores_gemma":[0.0001177761,0.00008250385,0.0002245401,0.000163669,0.0001243722,0.000287828,0.0003260871,0.0002684137,0.0004304315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000147491,"about_ca_system_score_gemma":0.0001545101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002757496,"about_ca_topic_score_gemma":0.0006241594,"domain_scores_codex":[0.9999626,0.000008693305,0.000001296818,0.000007277021,0.00000966513,0.00001047054],"domain_scores_gemma":[0.9999691,0.000002983437,0.000007615183,0.000002666932,0.00000676366,0.00001074344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002328627,0.0002300372,0.001004519,0.0003403836,0.00003992745,0.0006020985,0.00007099535,0.0008167879,0.9310526,0.002462452,0.001297141,0.06185016],"study_design_scores_gemma":[0.0001877142,0.003550167,0.00710654,0.0001211913,0.0001200785,0.001525308,0.0001929574,0.006521962,0.9046114,0.001542373,0.07447429,0.00004584325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335393,0.01374963,0.02155013,0.001234439,0.0001396032,0.0005820059,0.001217348,0.0002683323,0.02771928],"genre_scores_gemma":[0.9818626,0.005066747,0.007504228,0.0002178527,0.00003079248,0.0001012219,0.0004879726,0.00001014707,0.004718406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978004,"threshold_uncertainty_score":0.006617129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456791141241376,"score_gpt":0.2596309104000521,"score_spread":0.2450629989876383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}