{"id":"W4309006065","doi":"10.3390/antibiotics11111603","title":"Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; CYTED Ciencia y Tecnología para el Desarrollo","keywords":"Cathelicidin; Microbiology; Biology; Acinetobacter baumannii; Staphylococcus aureus; Antibiotics; Biofilm; Antibiotic resistance; Antimicrobial; Virology; Antimicrobial peptides; Bacteria; Pseudomonas aeruginosa; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045109,0.0001983022,0.0001662996,0.00009758141,0.00008973649,0.0002215393,0.0001347934,0.000214103,0.0006693209],"category_scores_gemma":[0.0002199718,0.00005740084,0.0001943041,0.00008465671,0.0001364898,0.000153912,0.0001726389,0.0003128287,0.00009439616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001603417,"about_ca_system_score_gemma":0.000233815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007782547,"about_ca_topic_score_gemma":0.001203353,"domain_scores_codex":[0.9999335,0.00001394434,0.000005760313,0.00001282639,0.0000196242,0.00001431144],"domain_scores_gemma":[0.9998978,0.0000181751,0.00003698573,0.000006632626,0.0000151777,0.00002522742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004731026,0.00004370814,0.002680213,0.0001854406,0.00001823508,0.0001993395,0.000020109,0.001213963,0.9836061,0.0001414427,0.0001362681,0.01128191],"study_design_scores_gemma":[0.0001368582,0.003703161,0.03779384,0.00008195949,0.0001175021,0.003154579,0.0001525042,0.02698664,0.9108674,0.0003706751,0.01659003,0.00004492551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946252,0.002443931,0.001866918,0.000126138,0.00002378673,0.00001451651,0.0002333744,0.00002849061,0.0006375356],"genre_scores_gemma":[0.995549,0.0007717158,0.002830111,0.00005548953,0.000008209972,0.000009280433,0.0002507999,0.000005473268,0.0005200423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007782547,"threshold_uncertainty_score":0.002239108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363422820254799,"score_gpt":0.2459057994344845,"score_spread":0.2322715712319365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}