{"id":"W4309012429","doi":"10.1101/2022.11.11.516192","title":"SUMO2 Protects Against Tau-induced Synaptic and Cognitive Dysfunction","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Fondazione Telethon; Howard Hughes Medical Institute","keywords":"SUMO protein; Tauopathy; Tau protein; Mutant; Neuroprotection; Genetically modified mouse; Transgene; Biology; Long-term potentiation; Cell biology; Gene isoform; Neuroscience; Chemistry; Alzheimer's disease; Neurodegeneration; Ubiquitin; Biochemistry; Medicine; Disease; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833092,0.0007172833,0.0004421698,0.0002811562,0.0002466509,0.000292298,0.0003542652,0.0004302315,0.001485744],"category_scores_gemma":[0.00009949891,0.0001725974,0.0005121373,0.0001883544,0.0002617497,0.0002073204,0.0002601731,0.0008583656,0.0003826622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370392,"about_ca_system_score_gemma":0.0003231535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006051793,"about_ca_topic_score_gemma":0.0008172873,"domain_scores_codex":[0.9999106,0.000007887927,0.00001191458,0.00001703199,0.0000244735,0.00002809845],"domain_scores_gemma":[0.9999024,0.000005289673,0.00002188652,0.0000173932,0.00001511231,0.00003787181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007279628,0.0002075878,0.0002743498,0.0001035955,0.00003330833,0.0001165801,0.00001737585,0.00009987425,0.9960299,0.000101482,0.000173259,0.002114631],"study_design_scores_gemma":[0.0001463665,0.001372629,0.007204425,0.00001806266,0.00005568521,0.0003568836,0.0000482723,0.0008195502,0.9871566,0.0001544593,0.002657784,0.00000921402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959549,0.001235759,0.0008455972,0.0001168336,0.00006770906,0.00003231357,0.0005481014,0.0001117477,0.001087035],"genre_scores_gemma":[0.9938053,0.001192669,0.0006812355,0.00009969281,0.00002002582,0.0000502232,0.001236876,0.000027468,0.002886499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001485744,"threshold_uncertainty_score":0.004970253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502698869941298,"score_gpt":0.2215593000067869,"score_spread":0.2065323113073739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}