{"id":"W4309013902","doi":"10.1093/neuonc/noac209.397","title":"DDDR-32. A NEW IMMUNOMODULATORY FUNCTION OF PYRIDO-PYRIMIDINE DERIVATIVES TO IMPAIR METASTATIC GROUP 3 MEDULLOBLASTOMA IN VIVO","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; Associazione Italiana per la Ricerca sul Cancro; Hospital for Sick Children; Lazio Innova","keywords":"Medulloblastoma; In vivo; Cancer research; Epithelial–mesenchymal transition; Vincristine; Medicine; Pharmacology; Biology; Oncology; Metastasis; Chemotherapy; Internal medicine; Chemistry; Cancer; Cyclophosphamide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000827219,0.0002845201,0.0001923943,0.0001860256,0.00009095656,0.0001122845,0.0001365938,0.0001899585,0.001840814],"category_scores_gemma":[0.00005871331,0.00006866629,0.0001724663,0.0001010004,0.0001158822,0.0001280199,0.00008764054,0.0004364715,0.000281065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001330696,"about_ca_system_score_gemma":0.0001761821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004448502,"about_ca_topic_score_gemma":0.000609084,"domain_scores_codex":[0.999951,0.00001063889,0.000004606916,0.0000103983,0.00001060429,0.00001275534],"domain_scores_gemma":[0.9999712,0.000004735967,0.000005937457,0.00000393201,0.00000353661,0.00001066272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004638454,0.0001860307,0.0001017694,0.0001242549,0.00001025889,0.00007185124,0.00001711074,0.0002056543,0.9930662,0.000163914,0.0001966713,0.005392414],"study_design_scores_gemma":[0.0002422934,0.003589841,0.002041093,0.00001484448,0.00003634042,0.000328162,0.00001590264,0.0007193572,0.9845632,0.00007427394,0.008365921,0.000008748558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871996,0.005179651,0.00284635,0.0002139233,0.00009803711,0.0001271458,0.0008660962,0.0001636596,0.003305635],"genre_scores_gemma":[0.9918689,0.002165329,0.002073785,0.00007399819,0.00001230785,0.00007373874,0.0008189248,0.00001174169,0.002901236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840814,"threshold_uncertainty_score":0.006158113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02272853773164618,"score_gpt":0.2898697955769201,"score_spread":0.2671412578452739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}